623141-56-0Relevant articles and documents
α-Keto amides as inhibitors of histone deacetylase
Wada, Carol K.,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Garland, Robert B.,Holms, James H.,Li, Junling,Pease, Lori J.,Guo, Jun,Glaser, Keith B.,Marcotte, Patrick A.,Richardson, Paul L.,Murphy, Shannon S.,Bouska, Jennifer J.,Tapang, Paul,Magoc, Terrance J.,Albert, Daniel H.,Davidsen, Steven K.,Michaelides, Michael R.
, p. 3331 - 3335 (2003)
α-Keto ester and amides were found to be potent inhibitors of histone deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The α-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model.
