59379-00-9Relevant academic research and scientific papers
Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization
Munnuri, Sailu,Adebesin, Adeniyi Michael,Paudyal, Mahesh P.,Yousufuddin, Muhammed,Dalipe, Alfonso,Falck, John R.
supporting information, p. 18288 - 18294 (2017/12/27)
Reliable regio- and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive due to the challenges of discriminating between multiple, relatively strong sp3 C-H bonds whose chemical behavior often differ onl
α-Keto amides as inhibitors of histone deacetylase
Wada, Carol K.,Frey, Robin R.,Ji, Zhiqin,Curtin, Michael L.,Garland, Robert B.,Holms, James H.,Li, Junling,Pease, Lori J.,Guo, Jun,Glaser, Keith B.,Marcotte, Patrick A.,Richardson, Paul L.,Murphy, Shannon S.,Bouska, Jennifer J.,Tapang, Paul,Magoc, Terrance J.,Albert, Daniel H.,Davidsen, Steven K.,Michaelides, Michael R.
, p. 3331 - 3335 (2007/10/03)
α-Keto ester and amides were found to be potent inhibitors of histone deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The α-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model.
Inhibitors of histone deacetylase
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, (2008/06/13)
Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Inhibitors of histone deacetylase
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, (2008/06/13)
Substituted trifluoromethyl ketones, ketooxazoles, ketoamides, ketoesters, and diketones having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the c
