623152-12-5

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-
• CAS NO: 623152-12-5
• Molecular Formula: C19H19N5O3
• Molecular Weight: 365.392
• Mol File: 623152-12-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-(623152-12-5)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-(623152-12-5)

Safety Data

• Hazardous Substances Data: 623152-12-5(Hazardous Substances Data)

Upstream product

• 2458-12-0 3-amino-p-toluic acid 
• 623155-19-1 3-amino-N-cyclopropyl-4-methylbenzamide 
• 427878-70-4 ethyl 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 427878-41-9 4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 
• 623152-11-4 ethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate 

Downstream Products

• 623152-17-0 BMS-582949 
• 623152-13-6 N-butyl-4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide 
• 761399-01-3 C₁₉H₁₈ClN₅O₂ 
• 623153-03-7 C₂₈H₂₆N₆O₂ 
• 623153-00-4 C₂₇H₂₄N₆O₂ 
• 623153-06-0 C₂₃H₂₁N₅O₃ 
• 623153-04-8 C₂₄H₂₄N₆O₂ 
• 623153-02-6 C₂₄H₂₄N₆O₂ 
• 623153-07-1 C₂₃H₂₂N₆O₂ 
• 623153-01-5 C₂₃H₂₂N₆O₂ 
• 623152-18-1 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-N-(2-methoxyethyl)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide 
• 623152-23-8 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-N,5-dimethylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide 
• 623152-27-2 (R)-4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-N-(2-hydroxy-1-phenylethyl)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide 
• 623152-26-1 (S)-N-sec-butyl-4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide 

Relevant articles and documents

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors

Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models o

Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein

Processes are provided for selectively preparing novel stable crystalline salt forms, selectively and consistently, namely, preparing Form N-1 of the methanesulfonic acid salt, and Form N-1 and Form N-4 of the hydrochloric acid salt of the p38 kinase inhibitor 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide. The processes preferably employ solvent systems including formic acid/acetone and formic acid/methylethyl ketone which produce crystals having suitable flow properties and desired particle size, and solvents such as N,N-dimethylformamide and N,N-dimethylacetamide may be employed as well. Novel Form N-1 crystals of the Form N-1 and Form N-4 crystals of the hydrochloride salt and Form N-1 crystals of the methanesulfonic acid salt of the above free base, pharmaceutical compositions containing such novel forms and a method of treating p38 kinase associated conditions, including rheumatoid arthritis are also provided.

PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS

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