623575-77-9Relevant academic research and scientific papers
Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b
Ruehl, Thomas,Daghish, Mohammed,Buchynskyy, Andrij,Barche, Karen,Volke, Daniela,Stembera, Katherina,Kempin, Uwe,Knoll, Dietmar,Hennig, Lothar,Findeisen, Matthias,Oehme, Ramona,Giesa, Sabine,Ayala, Juan,Welzel, Peter
, p. 2965 - 2981 (2003)
The interaction of a moenomycin derivative with the enzyme penicillin binding protein 1b (PBP 1b) has been studied by means of STD NMR. The results obtained initiated the synthesis of a number of moenomycin derivatives modified in unit A including a moenomycin-ampicillin conjugate and determination of their antibiotic activities. A protocol is described that allows studying the interaction of moenomycin analogues with PBP 1b by fluorescence correlation spectroscopy.
