623577-34-4

Basic information

• Product Name: 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate
• Synonyms: 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate
• CAS NO: 623577-34-4
• Molecular Formula: C₁₁H₈F₄N₂O₃S
• Molecular Weight: 324.25
• Product Categories: Pyrazole
• Mol File: 623577-34-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate(623577-34-4)
• EPA Substance Registry System: 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate(623577-34-4)

Safety Data

• Hazardous Substances Data: 623577-34-4(Hazardous Substances Data)

Usage

General Description

5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate is a chemical compound with the molecular formula C12H9F4N3O3S. It is a trifluoromethanesulfonate ester derivative of 5-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid. 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate is often used as a reagent in chemical reactions, particularly in the synthesis of pyrazole-containing compounds. It has been studied for its potential pharmacological properties and may have applications in medicinal chemistry and drug development. This chemical is a white to off-white solid, and its properties and behavior make it suitable for various laboratory and industrial processes.

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 623577-33-3 5-(4-fluorophenyl)-3-hydroxy-1-methyl-1H-pyrazole 
• 623577-33-3 5-(4-fluorophenyl)-1-methyl-1, 2-dihydropyrazol-3-one 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 

Downstream Products

• 777953-41-0 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yl]benzorlitrile 
• 686344-12-7 C₂₃H₂₁FN₂O 

Relevant articles and documents

Gamma-secretase inhibitors

Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.

SULFONAMIDES, SULFAMATES AND SULFAMIDES AS GAMMA-SECRETASE INHIBITORS

Compounds of formula I inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles via palladium-catalysed coupling to 3(5)-pyrazolyl nonaflates

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles were developed, based on Pd-catalysed couplings to 1-methyl-3(5)-arylpyrazole nonaflates, which offered an advantage in hydrolytic stability over the corresponding triflates. The new bifunctional reagent 1-methyl-3-bromo-pyrazol- 5-yl nonaflate underwent highly chemoselective Pd-catalysed couplings to the nonaflate, followed by Suzuki couplings to the bromide, allowing sequential, regioselective introduction of the two aryl substituents.