623577-34-4

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate is used as a reagent for the synthesis of pyrazole-containing compounds, which have potential pharmacological properties. This makes it valuable in medicinal chemistry and drug development, contributing to the creation of new therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate serves as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the exploration of new chemical pathways and the development of innovative synthetic methods.
Used in Laboratory Processes:
5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate is utilized in laboratory processes due to its stability and reactivity. It aids in the execution of complex chemical reactions, facilitating the advancement of scientific knowledge and the discovery of new chemical entities.
Used in Industrial Applications:
5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate is also employed in industrial applications where its reactivity and properties are leveraged to produce a range of products. Its versatility in chemical reactions makes it a valuable component in the manufacturing of various chemical and pharmaceutical products.
Used in Material Science:
5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yltrifluoromethanesulfonate may have applications in material science, where its unique properties can be harnessed to develop new materials with specific characteristics, such as improved stability or reactivity, for use in various industries.

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 623577-33-3 5-(4-fluorophenyl)-3-hydroxy-1-methyl-1H-pyrazole 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 
• 623577-33-3 5-(4-fluorophenyl)-1-methyl-1, 2-dihydropyrazol-3-one 

Downstream Products

• 686344-12-7 C₂₃H₂₁FN₂O 
• 777953-41-0 3-[5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yl]benzorlitrile 

Relevant academic research and scientific papers

Gamma-secretase inhibitors

Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.

CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE

Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.

SULFONAMIDES, SULFAMATES AND SULFAMIDES AS GAMMA-SECRETASE INHIBITORS

Compounds of formula I inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE

The compounds of formula (I): inhibit gamma-secretase and hence are of utility in the treatment or prevention of Alzheimer's disease.

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles via palladium-catalysed coupling to 3(5)-pyrazolyl nonaflates

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles were developed, based on Pd-catalysed couplings to 1-methyl-3(5)-arylpyrazole nonaflates, which offered an advantage in hydrolytic stability over the corresponding triflates. The new bifunctional reagent 1-methyl-3-bromo-pyrazol- 5-yl nonaflate underwent highly chemoselective Pd-catalysed couplings to the nonaflate, followed by Suzuki couplings to the bromide, allowing sequential, regioselective introduction of the two aryl substituents.

HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE

Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.