623577-33-3

Basic information

• Product Name: 5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one
• Synonyms: 5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one;5-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-3(2H)-ONE
• CAS NO: 623577-33-3
• Molecular Formula: C₁₀H₉FN₂O
• Molecular Weight: 192.19
• Product Categories: Pyrazole
• Mol File: 623577-33-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.264±0.06 g/cm3(Predicted)
• PKA: 8.45±0.70(Predicted)
• CAS DataBase Reference: 5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one(623577-33-3)
• EPA Substance Registry System: 5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one(623577-33-3)

Safety Data

• Hazardous Substances Data: 623577-33-3(Hazardous Substances Data)

Usage

General Description

5-(4-Fluoro-phenyl)-1-methyl-1,2-dihydropyrazol-3-one is a chemical compound with potential applications in the pharmaceutical industry. It is a type of dihydropyrazolone, which is a heterocyclic compound with a five-membered ring. The presence of a 4-fluoro-phenyl group and a methyl group in the chemical structure suggests that it may have interesting biological activities, potentially targeting specific receptors or enzymes in the body. Further research and testing are needed to determine the exact pharmacological properties and potential uses of this compound.

Upstream product

• 2928-14-5 3-(4-Fluorophenyl)propionic acid,methyl ester 
• 60-34-4 methylhydrazine 
• 42122-44-1 methyl 3-(4-fluorophenyl)propiolate 
• 1736-31-8 ethyl 3-(4-fluorophenyl)propiolate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 

Downstream Products

• 623577-34-4 trifluoromethanesulfonic acid 5-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yl ester 
• 699010-08-7 1-methyl-3⁽⁵⁾-(4-fluorophenyl)-pyrazole nonaflate 

Relevant articles and documents

Consecutive Three-Component Coupling-Addition Synthesis of β-Amino Enoates and 3-Hydroxypyrazoles via Ethyl 3-Arylpropiolates

Two consecutive three-component syntheses furnishing β-amino enoates or 3-hydroxypyrazoles based upon the Sonogashira alkynylation of aryl iodides and ethyl propiolate were established in mostly excellent yields. The ethyl 3-arylpropiolate intermediates are Michael systems which are suited for concatenation with conjugate addition or cyclocondensation giving access to libraries of 21 different β-amino enoates and 17 different 3-hydroxypyrazoles. The rotational barrier of β-pyrrolidino enoates was assessed by studying the coalescence of pyrrolidinyl protons in VT-NMR spectra of electronically different substituted derivatives showing that the electronic substituent effect on the aryl group does not affect the height of the rotational barrier. This indicates that the substituents are essentially oriented orthogonally to the plane of the β-pyrrolidino enoates.

PYRAZOLE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS USEFUL IN THE TREATMENT OF ALZHEIMER’S DISEASE

The compounds of formula (I): inhibit gamma-secretase and hence are of utility in the treatment or prevention of Alzheimer's disease.

SULFONAMIDES, SULFAMATES AND SULFAMIDES AS GAMMA-SECRETASE INHIBITORS

Compounds of formula I inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.