62358-73-0

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-7-METHYL-1-INDANONE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural sector, 5-CHLORO-7-METHYL-1-INDANONE is utilized as an intermediate in the production of agrochemicals. Its role in the synthesis of these chemicals contributes to the development of effective crop protection products and other agricultural applications.
Safety Considerations:
Due to its potential hazards, 5-CHLORO-7-METHYL-1-INDANONE must be handled with care. It is essential to follow strict safety protocols to ensure the well-being of workers and the protection of the environment during its use in both the pharmaceutical and agricultural industries.

Upstream product

• 856072-86-1 3-chloro-1-(4-chloro-2-methyl-phenyl)-propan-1-one 
• 108-41-8 1-chloro-3-methylbenzene 
• 62358-81-0 1-(bromomethyl)-3-chloro-5-methylbenzene 
• 50-00-0 formaldehyd 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 108-59-8 malonic acid dimethyl ester 
• 556-97-8 1-chloro-3,5-dimethylbenzene 
• 7664-93-9 sulfuric acid 
• 62358-63-8 3-(3-Chloro-5-methyl-phenyl)-propionic acid 
• 62358-62-7 2-(3-Chloro-5-methyl-benzyl)-malonic acid dimethyl ester 

Relevant academic research and scientific papers

Synthesis method of 1-indanone compounds

The present invention provides a synthesis method of 1-indanone compounds. The method comprises the following steps: adding benzoic acid compounds, dimethyl malonate, paraformaldehyde, a rhodium catalyst and an alkali to an organic solvent, heating under a nitrogen gas condition to carry out a reaction, and after the reaction is complete, carrying out post-treatment to obtain the 1-indanone compounds. The provided synthesis method of the 1-indanone compounds is simple and convenient to operate, the substrate is cheap and easy to obtain, wide in universality and good in functional group compatibility, and a simple and efficient method is provided for synthesizing indanone derivatives with diversified structures.

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.