62360-16-1Relevant academic research and scientific papers
Preparative resolution of bromocyclopropylcarboxylic acids
Edwards, Andrew,Ryabchuk, Pavel,Barkov, Alexey,Rubina, Marina,Rubin, Michael
, p. 1537 - 1549 (2015/02/02)
A general and efficient method for the preparative resolution of α- and β-bromocyclopropylcarboxylic acids has been developed. This protocol involves a sequence of two crystallizations with pseudo-enantiomeric amines, cinchonine, and cinchonidine, which yield both enantiomers of the acid in highly enriched form. Both alkaloids can be easily recovered and reused multiple times without any loss of efficacy.
