62365-78-0

Usage

Uses

Used in Scientific Research:
3-Ethynyl-indole is used as a research compound for [application reason] in the field of organic chemistry. It is particularly valuable for studying the properties and reactions of indole-based compounds, as well as for the synthesis of more complex molecules.
Used in Organic Chemistry:
3-Ethynyl-indole is used as a building block for [application reason] in the synthesis of various organic molecules. Its unique structure allows for the formation of new bonds and the creation of novel chemical entities, which can be further explored for potential applications in various industries.
Used in Pharmaceutical Development:
3-Ethynyl-indole is used as a potential drug candidate for [application reason] in the development of new pharmaceuticals. Its indole core and ethynyl group may provide unique interactions with biological targets, making it a promising starting point for the design of new therapeutic agents.
Note: The specific application reasons for each use have been omitted as they were not provided in the materials. However, they can be filled in based on the intended purpose or the properties of 3-Ethynyl-indole that make it suitable for each application.

Upstream product

• 68588-31-8 5-[(1H-indol-3-yl)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1377861-02-3 3-((trimethylsilyl)ethynyl)-1H-indole 
• 1308378-58-6 3-trimethylsilanylethynylindole-1-carboxylic acid tert-butyl ester 
• 120-72-9 indole 
• 1204778-28-8 3-((triisopropylsilyl)ethynyl)-1H-indole 

Downstream Products

• 765914-04-3 3-ethynyl-1-(toluene-4-sulfonyl)-1H-indole 
• 74306-95-9 1-(3-indolyl)-4-phenyl-1,3-butadiyne 
• 62365-79-1 1,4-di(3-indolyl)-1,3-butadiyne 

Relevant academic research and scientific papers

Rapid synthesis of indole cis-enamides via hydroamidation of indolic alkynes

The synthesis of indolic cis-enamides using a ruthenium-mediated hydroamidation of indole alkynes with primary oxalamides or α-keto amides is reported. Using this method the total synthesis of igzamide and Z-coscinamides A and B has been achieved.

SELECTIVE ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM

In alternative embodiments, provided are selective agonists having a high affinity for the alpha7 nicotinic acetylcholine receptor (α7 nAChR), assays for selectivity of nicotinic receptor subtype and ligand-gated ion channel subtype based on receptor occupation and response, behavioral assessments for reversing cognitive impairment after scopolamine treatment, enhancing memory retention over time, pharmaceutical compositions and formulations and devices comprising them, and methods for making and using them, including characterizing and efficiently assaying them for receptor subtype selectivity. In alternative embodiments, provided are substituted anti 1,2,3-triazoles compounds with high affinity, and selective binding, for the alpha7 nicotine acetylcholine receptor (α7 nAChR), as exemplified by 5-(1-(2-(Piperidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND1”), 5-((quinuclid-3-yl)-1H-1,2,3-triazol-4-yl)-1H-indole (“IND8”) and 3-(4-hydroxyphenyl-1,2,3-triazol-1-yl) quinuclidine (“QND8”). In alternative embodiments, provided are products of manufacture such as pumps, devices, syringes and the like comprising a compound, pharmaceutical composition or formulation as provided herein.

Direct alkynylation of indole and pyrrole heterocycles

Chemical Equitation Presentation Easy does it: The unique properties of benziodoxolone alkynyl periodinane l and gold catalysts have allowed the development of a high yielding, operationally simple (room temperature, no dry sol-vents or inert conditions, commercially available catalyst) reaction for the introduction of silylacetylenes on a large range of indole and pyrrole heterocycles with a wide range of functional groups (see scheme).

Flash Vacuum Pyrolysis of 5-(Indol-2- and -3-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-diones

Flash vacuum pyrolysis of 5-(indol-2- and -3-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-diones results in the initial formation of indolylmethyleneketenes, which generally either lose carbon monoxide to produce ethynylindoles or undergo -sigmatropic shifts, followed by electrocyclic rearrangements, to yield carbazolols or benzindol-5(1H)-one. 5-(Indol-2-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione and the 3-methylindol-2-yl derivative both yield 3H-pyrroloindol-3-ones via a -sigmatropic rearrangement of the initially formed ketene.