62366-56-7

Usage

InChI:InChI=1/C6H5F3N2O/c1-11-3-2-10-5(11)4(12)6(7,8)9/h2-3H,1H3

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1011426-33-7 1-(5-amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2,2,2-trifluoro-1-(1-methyl-1H-imidazol-2-yl)ethanol 
• 882226-74-6 1-[5-amino-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]-2,2,2-trifluoro-1-(1-methyl-1H-imidazol-2-yl)ethanol 
• 1259501-14-8 4-chloro-N-[2,2,2-trifluoro-1-(1-methyl-1H-imidazole-2-yl)ethyl]aniline 
• 1330660-14-4 4-chloro-N-[1,1,1-trifluoro-2-(1-methyl-1H-imidazole-2-yl)propan-2-yl]aniline 

Relevant academic research and scientific papers

Enantioselective Alkynylation of 2-Trifluoroacetyl Imidazoles Catalyzed by Bis-Cyclometalated Rhodium(III) Complexes Containing Pinene-Derived Ligands

Chiral rhodium(III) complexes containing two cyclometalating 2-phenyl-5,6-(S,S)-pinenopyridine ligands and two additional acetonitriles are introduced as excellent catalysts for the highly enantioselective alkynylation of 2-trifluoroacetyl imidazoles. Whe

Synthesis, Stability, and Photoreactivity of Diazirinyl-Substituted N-Heterocycles Based on Indole, Benzimidazole, and Imidazole

The synthesis, thermal stability, and photoreactivity of trifluoromethyl diazirines installed at the heterocyclic section of N-methylindole, N-methylbenzimidazole, and at N-methylimidazole were investigated. N-Tosyl-3-diazirinylindole and N-methyl-2-diazirinylbenzimidazole proved to be thermally stable, whereas the corresponding 2-diazirinylindole was not. The least stable was 2-diazirinylimidazole, which underwent rapid decomposition. Quenching with ethanol indicated that the corresponding carbene was formed. Decomposition is rationalized by exothermic coarctate ring-opening of the carbene. Quantum mechanical calculations [B3LYP/6-311G(2d,2p)] predict singlet ground states of all carbenes. Accordingly, Friedel-Crafts alkylation products were formed on irradiation (350 nm, Rayonet) of the N-methylbenzimidazole-based diazirine in the presence of phenol.

2-(Trifluoroacetyl)imidazoles, 2-trifluoroacetyl-1,3-thiazoles, and 2-trifluoroacetyl-1,3-oxazoles

A facile method of trifluoroacylation of imidazoles, 1,3-thiazoles, and 1,3-oxazoles with trifluoroacetic anhydride resulted in a set of heterocyclic trifluoromethyl-containing ketones. Unlike common ketones, these compounds form stable hydrates and enter into noncatalytic ene reactions with terminal olefins affording the corresponding allyl alcohols. Georg Thieme Verlag Stuttgart.