62375-96-6Relevant academic research and scientific papers
Facile access to 1,3-diketones by gold(i)-catalyzed regioselective hydration of ynones
Kuang, Jinqiang,Zhou, Tao,You, Tingjie,Chen, Jianhui,Su, Chenliang,Xia, Yuanzhi
supporting information, p. 3940 - 3944 (2019/04/30)
A facile and efficient synthesis of 1,3-diketones was developed by the gold(i)-catalyzed regioselective hydration of ynones at room temperature. This methodology employed 2.5 mol% of PPh3AuCl and 3 mol% of AgOTf as a simple catalytic system wit
Enantioselective Stereodivergent Nucleophile-Dependent Isothiourea-Catalysed Domino Reactions
Matviitsuk, Anastassia,Taylor, James E.,Cordes, David B.,Slawin, Alexandra M. Z.,Smith, Andrew D.
supporting information, p. 17748 - 17757 (2016/11/29)
α,β-Unsaturated acyl ammoniums generated from the reaction of α,β-unsaturated 2,4,6-trichlorophenol (TCP) esters bearing a pendent enone with an isothiourea organocatalyst are versatile intermediates in a range of enantioselective nucleophile-dependent domino processes to form complex products of diverse topology with excellent stereoselectivity. Use of either 1,3-dicarbonyls, acyl benzothiazoles, or acyl benzimidazoles as nucleophiles allows three distinct, diastereodivergent domino reaction pathways to be accessed to form various fused polycyclic cores containing multiple contiguous stereocentres.
