6238-34-2

Basic information

• Product Name: Quinuclidine-3-carboxylic acid hydrochloride
• Synonyms: Quinuclidine-3-carboxylic acid hydrochloride;1-Azabicyclo[2.2.2]octane-3-carboxylic acid hydrochloride
• CAS NO: 6238-34-2
• Molecular Formula: C₈H₁₃NO₂*ClH
• Molecular Weight: 191.65526
• Product Categories: Intermediates
• Mol File: 6238-34-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 271-273℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Quinuclidine-3-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Quinuclidine-3-carboxylic acid hydrochloride(6238-34-2)
• EPA Substance Registry System: Quinuclidine-3-carboxylic acid hydrochloride(6238-34-2)

Safety Data

• Hazardous Substances Data: 6238-34-2(Hazardous Substances Data)

Usage

General Description

Quinuclidine-3-carboxylic acid hydrochloride is a chemical compound with potential pharmaceutical applications. It is a salt form of quinuclidine-3-carboxylic acid, which is a derivative of quinuclidine, a heterocyclic amine. Quinuclidine-3-carboxylic acid hydrochloride is often used as a building block in the synthesis of various pharmaceutical compounds and has potential uses in the development of drugs for the treatment of various medical conditions. It acts as a precursor in the preparation of medicinally important molecules and is also used as a chiral auxiliary in chemical synthesis. Quinuclidine-3-carboxylic acid hydrochloride is an important reagent in organic chemistry and has promising applications in the pharmaceutical industry.

Upstream product

• 38206-86-9 methyl quinuclidine-3-carboxylate 
• 6238-33-1 3-quinuclidinecarboxylic acid ethyl ester 
• 51627-76-0 3-Cyano-1-azabicyclo[2.2.2]octane 

Downstream Products

• 1404054-99-4 (4-methoxyphenyl)(phenyl)methyl quinuclidine-3-carboxylate 
• 1404054-89-2 1-benzyl-3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1404055-12-4 3-((9H-fluoren-9-yloxy)carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1404054-93-8 bis(4-fluorophenyl)methyl quinuclidine-3-carboxylate 
• 1404054-95-0 3-((bis(4-fluorophenyl)methoxy)carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1404055-01-1 (2-chlorophenyl)(4-chlorophenyl)methyl quinuclidine-3-carboxylate 
• 1404055-03-3 3-(((2-chlorophenyl)(4-chlorophenyl)methoxy)-carbonyl)-1-(2-oxo-2-(thiophen-3-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1404054-25-6 bis(4-chlorophenyl)methyl quinuclidine-3-carboxylate 
• 1404055-04-4 (3,4-difluorophenyl)(phenyl)methyl quinuclidine-3-carboxylate 
• 1404055-06-6 3-fluorobenzyl quinuclidine-3-carboxylate 
• 1404055-08-8 3-((3-fluorobenzyloxy)carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1404054-91-6 3-((1,2-diphenylethoxy)carbonyl)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1404054-24-5 1,2-diphenylethyl quinuclidine-3-carboxylate 
• 1404054-23-4 bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate 

Relevant articles and documents

SYNTHESIS OF 1,3-DIMETHYL-8-(QUINUCLID-3-YL)XANTHINE AND ITS INVESTIGATION

-

Synthesis and Muscarinic Activities of Quinuclidin-3-yltriazole and -tetrazole Derivatives

The synthesis of 15 methyl or unsubstituted 1,2,3-triazoles, 1,2,4-triazoles, and tetrazoles additionally substituted with a 1-azabicyclooctan-3-yl group is described.The potency and efficacy of these compounds as muscarinic ligands were determined in radioligand binding assays using oxotremorine and quinuclidinyl benzilate.Potency and efficacy were found in compounds in which the azole moiety was attached to the azabicyclic ring either through a carbon atom or a nitrogen atom.Electrostatic potential maps of both the C-linked and the novel N-linked series of compounds were calculated.A relationship between position and depth of the electrostatic minima relative to the azabicyclic ring and the potency and efficacy of the compounds was determined.