51627-76-0

Basic information

• Product Name: 1-azabicyclo[2.2.2]octane-3-carbonitrile
• Synonyms: 1-azabicyclo[2.2.2]octane-3-carbonitrile
• CAS NO: 51627-76-0
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19428
• Mol File: 51627-76-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 248.8°Cat760mmHg
• Flash Point: 104.1°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 0.0238mmHg at 25°C
• Refractive Index: 1.532
• PKA: 8.12±0.33(Predicted)
• CAS DataBase Reference: 1-azabicyclo[2.2.2]octane-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-azabicyclo[2.2.2]octane-3-carbonitrile(51627-76-0)
• EPA Substance Registry System: 1-azabicyclo[2.2.2]octane-3-carbonitrile(51627-76-0)

Safety Data

• Hazardous Substances Data: 51627-76-0(Hazardous Substances Data)

Usage

Structure

Bicyclic organic compound containing a nitrogen atom.

Usage

Commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals.

Importance

Unique bicyclic structure and the presence of a nitrile group make it a valuable intermediate in the pharmaceutical industry.

InChI:InChI=1/C8H12N2/c9-5-8-6-10-3-1-7(8)2-4-10/h7-8H,1-4,6H2

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 74384-65-9 quinuclidin-2-one 
• 39085-59-1 trisylhydrazine 
• 3731-38-2 3-Quinuclidinone 
• 151-50-8 potassium cyanide 

Downstream Products

• 5176-21-6 1-azabicyclo[2.2.2]octane-3-carboxaldehyde 
• 132668-74-7 1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-2-phenyl-1-o-tolyl-ethanol 
• 102723-03-5 C₁₅H₂₁NO 
• 60697-87-2 o-tolyl(quinuclidin-3-yl)methanone 
• 1428324-03-1 2-phenyl-1-(quinuclidin-3-yl)ethanone 
• 6238-34-2 1-azabicyclo<2.2.2>octane-3-carboxylic acid hydrochloride 
• 604803-77-2 (R)-1-azabicyclo[2.2.2]octane-3-carbonitrile 
• 93117-84-1 3-Acetyl-1-azabicyclo[2.2.2]octane 
• 123837-16-1 1-azabicyclo<2.2.2>octane-3-carboxamide amidoxime 
• 75208-40-1 quinuclidine-3-carboxylic acid 

Relevant articles and documents

Synthesis and in vitro muscarinic activities of a series of 3-(pyrazol- 3-yl)-1-azabicyclo[2.2.2]octanes

A series of 3-(pyrazol-3-yl)-1-azabicyclo[2.2.2]octane derivatives C (Fig. 1) was synthesized and tested for muscarinic activity in receptor binding assays using [3H]-oxotremorine-M (OXO-M) and [3H]-pirenzepine (PZ) as ligands. Potential muscarinic agonistic or antagonistic properties of the compounds were determined using binding studies measuring their potencies to inhibit the binding of OXO-M and PZ. Preferential inhibition of OXO-M binding was used as an indicator for potential muscarinic agonistic properties; this potential was confirmed in functional studies on isolated organs. (C) 2000 Elsevier Science Ltd.

N-biarylamides

The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.

N-BIARYLAMIDES

The invention relates to N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improvement in cognition, concentration power, learning power and/or memory.