6239-01-6Relevant academic research and scientific papers
Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors
Du, Xiaohui,Lizarzaburu, Mike,Turcotte, Simon,Lee, Taeweon,Greenberg, Joanne,Shan, Bei,Fan, Peter,Ling, Yun,Medina, Julio C.,Houze, Jonathan
, p. 3774 - 3779 (2011/08/06)
Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1.
Carboxylic Acid Compounds and Use Thereof
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Page/Page column 79, (2010/11/28)
Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: [image] wherein each symbol is as defined in the specification.
