623938-56-7Relevant academic research and scientific papers
Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes
Pallavicini, Marco,Moroni, Barbara,Bolchi, Cristiano,Cilia, Antonio,Clementi, Francesco,Fumagalli, Laura,Gotti, Cecilia,Meneghetti, Fiorella,Riganti, Loredana,Vistoli, Giulio,Valoti, Ermanno
, p. 5610 - 5615 (2007/10/03)
The RS and SR enantiomers of 2-oxazolidinone and 1,4-benzodioxane bearing a 2-pyrrolidinyl substituent at the 5- and 2-position, respectively, were synthesized as candidate nicotinoids. One of the two benzodioxane stereoisomers reasonably fits the pharmac
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists
Gavai, Ashvinikumar V.,Vaz, Roy J.,Mikkilineni, Amarendra B.,Roberge, Jacques Y.,Liu, Yalei,Lawrence, R. Michael,Corte, James R.,Yang, Wu,Bednarz, Mark,Dickson Jr., John K.,Ma, Zhengping,Seethala, Ramakrishna,Feyen, Jean H. M.
, p. 5478 - 5482 (2007/10/03)
A 3D quantitative structure-activity relationship study for inhibition of calcium-sensing receptor in the aryloxypropanolamine series predicted that these molecules adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypoth
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates
Dei, Silvia,Bellucci, Cristina,Buccioni, Michela,Ferraroni, Marta,Gualtieri, Fulvio,Guandalini, Luca,Manetti, Dina,Matucci, Rosanna,Romanelli, Maria Novella,Scapecchi, Serena,Teodori, Elisabetta
, p. 3153 - 3164 (2007/10/03)
Four out of the eight possible stereoisomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and the corresponding iodomethylates have been synthesised. They were formally derived from hybridisat
