624-58-8

Basic information

• Product Name: epicyanohydrin
• Synonyms: epicyanohydrin;2-Oxiraneacetonitrile
• CAS NO: 624-58-8
• Molecular Formula: OCH2CHCH2CN
• Molecular Weight: 83.0886
• Mol File: 624-58-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 198.5°Cat760mmHg
• Flash Point: 80.1°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 0.359mmHg at 25°C
• Refractive Index: 1.446
• CAS DataBase Reference: epicyanohydrin(CAS DataBase Reference)
• NIST Chemistry Reference: epicyanohydrin(624-58-8)
• EPA Substance Registry System: epicyanohydrin(624-58-8)

Safety Data

• Hazardous Substances Data: 624-58-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H5NO/c5-2-1-4-3-6-4/h4H,1,3H2

Upstream product

• 109-75-1 but-3-enenitrile 
• 106-89-8 epichlorohydrin 
• 105-33-9 4-chloro-3-hydroxybutyronitrile 

Downstream Products

• 13880-89-2 3-hydroxyglutaronitrile 

Relevant articles and documents

Preparation method of (S)-oxiracetam

The invention discloses a preparation method of (S)-oxiracetam. The preparation method is characterized by comprising the following steps that 1, 2-epoxy ethylacetamide is cyclized in molecules in the presence of a catalyst and alkali to obtain a compound (S)-3-hydroxyl-butyrolactam shown as a formula II; 2, the (S)-3-hydroxyl-butyrolactam obtained in the step 1 reacts with tertiary butyl methyl chlorosilane to obtain a compound protected by the tertiary butyl methyl chlorosilane and shown as a formula III; 3, the compound shown as the formula III performs nucleophilic reaction with bromoacetonitrile under the alkaline condition to obtain a N-cyanomethide shown as a formula IV; 4, the N-cyanomethide shown as the formula IV is subjected to hydrolysis under the acid condition to obtain the (S)-oxiracetam (shown in the description). The method adopts conventional non-achiral raw materials and is low in cost, the (S)-oxiracetam is high in yield, an ee value is high, and a new way is provided for preparation of the (S)-oxiracetam.

A short synthesis of 4-amino-3-hydroxybutyric acid (GABOB) via allyl cyanide

4-Amino-3-hydroxybutyric acid was synthesized from allyl cyanide in four steps in an overall yield of 38%. Ultrasonically promoted epoxidation of allyl cyanide with m-chloroperoxybenzoic acid giving oxiranylacetonitrile was used as a key step.