105-33-9

Basic information

• Product Name: 4-CHLORO-3-HYDROXY BUTYRONITRILE
• Synonyms: 4-CHLORO-3-HYDROXY BUTYRONITRILE;4-chloro-3-hydroxy-butanenitril;(4)-CHLORO-3-HYDROXYBUTYRONITRILE 98+%;3-Hydroxy-4-chlorobutyronitrile;4-Chloro-3-hydroxybutanenitrile;γ-Chloro-β-hydroxybutyronitrile;4-chloro 3-hydroxybu
• CAS NO: 105-33-9
• Molecular Formula: C₄H₆ClNO
• Molecular Weight: 119.55
• EINECS: 203-287-2
• Product Categories: Chiral Alcohols
• Mol File: 105-33-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 286.175 °C at 760 mmHg
• Flash Point: 126.875 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.000304mmHg at 25°C
• Refractive Index: 1.464
• PKA: 12.67±0.20(Predicted)
• CAS DataBase Reference: 4-CHLORO-3-HYDROXY BUTYRONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-HYDROXY BUTYRONITRILE(105-33-9)
• EPA Substance Registry System: 4-CHLORO-3-HYDROXY BUTYRONITRILE(105-33-9)

Safety Data

• Hazardous Substances Data: 105-33-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-Hydroxy Butyronitrile is a chemically synthesized compound known for its specific structure and properties. It is recognized for having a chlorine atom, a hydroxy group, and a nitrile group in its chemical structure. As with many chemicals, proper handling and safety measures need to be observed when working with 4-Chloro-3-Hydroxy Butyronitrile due to its potential for reactivity and toxicity. 4-CHLORO-3-HYDROXY BUTYRONITRILE is predominantly used in chemical reactions to produce other compounds or as an additive in certain industrial processes. Specific information about its properties, stability, reactivity, and possible health risks can be obtained from its Material Safety Data Sheet (MSDS).

InChI:InChI=1/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 143-33-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 
• 151-50-8 potassium cyanide 
• 106-89-8 epichlorohydrin 
• 109-75-1 but-3-enenitrile 
• 135908-05-3 2-hydroxy-3-chloropropyl p-toluenesulfonate 
• 128993-20-4 3-Bromo-5-chloromethyl-4,5-dihydro-isoxazole 
• 81091-27-2 4-chloro-3-trimethylsiloxybutyronitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 10488-68-3 methyl 4-chloro-3-hydroxybutanoate 
• 5388-37-4 3-Methyl-3-cyclohexyl-5-cyanmethyl-oxazolidinium chlorid 
• 5688-47-1 8-Methyl-3-cyanmethyl-2-oxa-8-aza-5-azonia-spiro<4.5>decan 
• 624-58-8 3,4-epoxybutanenitrile 
• 56208-05-0 (R)-4-chloro-3-propionyloxybutyronitrile 
• 56208-05-0 4-chloro-3-propionyloxybutyronitrile 
• 13880-89-2 3-hydroxyglutaronitrile 
• 40499-83-0 pyrrolidin-3-ol 
• 84367-31-7 (R)-γ-chloro-β-hydroxybutyronitrile 
• 127913-44-4 (S)-4-chloro-3-hydroxy butyronitrile 
• 29331-43-9 4-chloro-3-acetoxybutyronitrile 
• 74923-98-1 (R)-3,4-dihydroxybutanenitrile 
• 1116-95-6 (D)-(+)-carnitinenitrile chloride 
• 2788-28-5 (2R)-(-)-3-cyano-2-hydroxypropyltrimethylammonium chloride 

Relevant articles and documents

Nitrilase-catalysed desymmetrisation of 3-hydroxyglutaronitrile: Preparation of a statin side-chain intermediate

An efficient, scaleable synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate, a potential intermediate in the synthesis of Atorvastatin (Lipitor), has been developed. The three-stage process starts with reaction of low-cost epichlorohydrin with cyanide to give 3-hydroxyglutaronitrile (3-HGN). The second stage utilises a nitrilase-catalysed desymmetrisation of 3-HGN. The nitrilase reaction has been optimized to work at 3 M (330 g/L) substrate concentration, pH 7.5,27 °C. Under these conditions, with an enzyme loading of 6 wt %, 100% conversion and 99% ee product is obtained in 16 h. This material is then esterified to give the target compound, ethyl (R)-4-cyano-3-hydroxybutyrate. The cost-effectiveness of the process is determined by three factors: use of a low-cost starting material, the introduction of the chiral centre by desymmetrisation as opposed to kinetic resolution, and the use of Pfenex Expression Technology to allow a lower-cost supply of biocatalyst.

Regiospecific opening of 1,2-epoxides with acetone cyanohydrin under mildly basic conditions

Acetone cyanohydrin with stoichiometric triethylamine opens epoxides regiospecifically to give β-hydroxy nitriles. As expected, addition of cyanide occurs at the least substituted carbon.

A new method for the preparation of β-hydroxy nitriles; Transformation of 3-bromo-2-isoxazolines to β-hydroxy nitriles by treatment of alkanethiolates

3-Bromo-2-isoxazolines are transformed to β-hydroxy nitriles in good yields by treatment with alkanethiolates under a very mild condition.

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The resolution of (plus or minus)-carnitine and the synthesis of acylcarnitines.

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A Cyanide-free Biocatalytic Process for Synthesis of Complementary Enantiomers of 4-Chloro-3-hydroxybutanenitrile From Allyl Chloride

A biocatalyst used for selective ring scission of (±)-5-(chloromethyl)-4, 5-dihydroisoxazole to synthesize chiral (R)-4-chloro-3-hydroxybutanenitrile (90 % ee, 39 % isolated yield) and (S)-5-(chloromethyl)-4, 5-dihydroisoxazole (99 % ee, 39 % isolated yield) was developed by site-saturated mutagenesis on aldoxime dehydratase derived from Pseudomonas chlororaphis B23 (OxdA). The positive mutant (OxdA-L318I, E=68) improved the enantiomeric ratio E by 6-fold as compared to the wild type enzyme (OxdA-wild, E=11). The racemic precursor of (±)-5-(chloromethyl)-4, 5-dihydroisoxazole, used in the reaction, can be synthesized from readily available allyl chloride without utilizing highly toxic cyanide. The enantiopure (S)-5-(chloromethyl)-4, 5-dihydroisoxazole remaining in the kinetic resolution can be transformed into corresponding chiral (S)-4-chloro-3-hydroxybutanenitrile without loss of enantiomeric excess by treating it with triethylamine in acetonitrile (99 % ee, 72 % isolated yield) or catalysis of OxdA-wild enzyme (99 % ee, 88 % isolated yield).

Preparation method of 1-BOC-3-hydroxymethyl pyrrolidine

The invention discloses a preparation method of 1-Boc-3-hydroxymethyl pyrrolidine. The preparation method uses epichlorohydrin as a raw material, 3-hydroxymethyl pyrrolidine is obtained through reduction and cyclization reaction, then the 1-Boc-3-hydroxymethyl pyrrolidine is prepared through Boc protection reaction, then 1-BOC-3-methyl formate pyrrolidine is prepared through carboxylation reaction and esterification reaction, and finally the 1-BOC-3-methyl formate pyrrolidine and lithium aluminum hydride are catalyzed by a catalyst to prepare the 1-BOC-3-hydroxymethyl pyrrolidine. The preparation method is high in product synthesis rate, high in product purity and low in production cost, and the raw materials are cheap and easy to obtain.

LiOH-catalyzed simple ring opening of epoxides under solvent-free conditions

LiOH has been found to be a very simple and selective catalyst for the rapid and mild synthesis of β-hydroxy sulfides and β-hydroxyl nitriles by ring opening of epoxides with aromatic, aliphatic, and heterocyclic thiols and trimethylsilyl cyanide at room temperature under solvent free conditions. All the reactions proceeded satisfactorily in short times and afforded the corresponding products in good to excellent yields with high regioselectivity and chemoselectivity under mild reaction conditions. Copyright Taylor & Francis Group, LLC.