62438-02-2

Usage

Function

Antibiotic medication for treating tuberculosis

Mechanism of Action

Inhibits production of mycolic acids in bacterial cell wall

Typical Usage

First-line treatment for tuberculosis, often used in combination with other medications

Side Effects

Potential for liver toxicity and nerve damage

Importance

Critical tool in fighting against tuberculosis, successfully used for decades to treat and prevent spread of disease.

Upstream product

• 29065-91-6 isoxazole-3-carboxamide 
• 1254073-72-7 1,1-dimethylethyl 2-(3-isoxazolylcarbonyl)hydrazinecarboxylate 

Relevant academic research and scientific papers

Compounds Which Selectively Modulate The CB2 Receptor

Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.