62458-64-4

Basic information

• Product Name: 1-(2-Hydroxy-5-acetylphenyl)-3-methyl-1-butanone
• Synonyms: 1-(2-Hydroxy-5-acetylphenyl)-3-methyl-1-butanone;1-(5-Acetyl-2-hydroxyphenyl)-3-methyl-1-butanone
• CAS NO: 62458-64-4
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.26
• Mol File: 62458-64-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 64–66°C
• Appearance: /
• CAS DataBase Reference: 1-(2-Hydroxy-5-acetylphenyl)-3-methyl-1-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Hydroxy-5-acetylphenyl)-3-methyl-1-butanone(62458-64-4)
• EPA Substance Registry System: 1-(2-Hydroxy-5-acetylphenyl)-3-methyl-1-butanone(62458-64-4)

Safety Data

• Hazardous Substances Data: 62458-64-4(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of p-acetylphenyl isovalerate without solvent in the presence of aluminium chloride at 140–160° for 2.5 h (51%) or at 150° for 3 h (32%).

Upstream product

• 108-12-3 isopentanoyl chloride 
• 99-93-4 4-Hydroxyacetophenone 
• 92757-71-6 Benzoic acid 4-acetyl-2-(3-methyl-butyryl)-phenyl ester 
• 73618-86-7 3-Methyl-butyric acid 4-acetyl-phenyl ester 

Downstream Products

• 73618-90-3 1-[5-Acetyl-2-(1,1-dimethyl-prop-2-ynyloxy)-phenyl]-3-methyl-butan-1-one 
• 73618-91-4 1-[5-Acetyl-2-(1,1-dimethyl-allyloxy)-phenyl]-3-methyl-butan-1-one 
• 54963-42-7 Piloselloidon 
• 51995-99-4 1-(5-acetyl-2-methoxyphenyl)-3-methylbut-2-en-1-one 
• 54963-37-0 6-acetyl-8-isovaleryl-2,2-dimethyl-chromene 
• 92757-75-0 6-Acetyl-3-isopropyl-2-phenyl-chromen-4-one 
• 51995-98-3 espeletone 
• 92757-71-6 Benzoic acid 4-acetyl-2-(3-methyl-butyryl)-phenyl ester 

Relevant articles and documents

FURTHER 5-METHYL COUMARINS AND OTHER CONSTITUENTS FROM THE SUBTRIBE MUTISINAE

Key Word Index-Mutisia spinosa, M. retorsa; Trichocline sinuata; Brachyclados megalanthus; Compositae; chemotaxonomy; 5-methyl coumarins; monoterpenes; geraniol and linalol derivatives; C14-acetylenic compound.The investigation of four species from the subtribe Mutisiinae afforded eight new monoterpenes, seven 5-methyl coumarins, two closely related 5-methyl chromones, two coumarane derivatives, a p-hydroxy acetophenone derivative and a new C14-acetylene.The structures were elucidated by spectroscopic methods and a few chemical transformations.The chemotaxonomy of the Mutisiinae is discussed.

Synthesis of Naturally Occurring p-Hydroxyacetophenone Derivatives, II

The structures of ten hydroxyacetophenone derivatives isolated from Composites (3-5, 7, 11, 12, 14, 16, 23, and 24) have been finally established by synthesis.