73618-86-7

Upstream product

• 108-12-3 isopentanoyl chloride 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 73618-90-3 1-[5-Acetyl-2-(1,1-dimethyl-prop-2-ynyloxy)-phenyl]-3-methyl-butan-1-one 
• 73618-91-4 1-[5-Acetyl-2-(1,1-dimethyl-allyloxy)-phenyl]-3-methyl-butan-1-one 
• 54963-42-7 Piloselloidon 
• 51995-99-4 1-(5-acetyl-2-methoxyphenyl)-3-methylbut-2-en-1-one 
• 51995-98-3 espeletone 
• 54963-37-0 6-acetyl-8-isovaleryl-2,2-dimethyl-chromene 
• 92757-71-6 Benzoic acid 4-acetyl-2-(3-methyl-butyryl)-phenyl ester 
• 92757-75-0 6-Acetyl-3-isopropyl-2-phenyl-chromen-4-one 
• 62458-64-4 4'-hydroxy-3'-(3-methylbutanoyl)acetophenone 

Relevant academic research and scientific papers

Synthesis of 6-Acetyl-3-alkyl-2-phenyl-chromen-4-ones by Phasetransfer Catalysed Baker-Venkataraman Reaction

Three of the five partial steps of the Baker-Venkataramansynthesis of flavones (scheme 1) can be flavoured by PTC conditions.In the intermolecular O-acylations of the 4-hydroxyacetophenone 1 (A) and the 5-acetyl-2-hydroxy-acylophenones 3 (C), respectively, the nucleophilicity of the phenolat anions is increased by the PT catalysator.The steric and electronic effects of the substituents in the 5-acetyl-2-benzoyloxy-acylophenones 4 cause the formation of the 6-acetyl-flavones 6 in the phasetransfer catalysed Baker-Venkataraman rearrangement (D) in one step and in good yields.The over-all yields of the 1 -> 6 reactions are not higher than 30percent because of the limiting step (B).This Fries rearrangement of 4-acyloxy-acetophenones 2 affords only 32-62percent of 3 under drastically enhanced conditions.

Synthesis of Naturally Occurring p-Hydroxyacetophenone Derivatives, II

The structures of ten hydroxyacetophenone derivatives isolated from Composites (3-5, 7, 11, 12, 14, 16, 23, and 24) have been finally established by synthesis.