62465-90-1

Usage

InChI:InChI=1/C9H8Cl2N2O2/c1-15-9(14)8(11)13-12-7-4-2-6(10)3-5-7/h2-5,12H,1H3/b13-8-

Upstream product

• 4755-81-1 methyl 2-chloroacetoacetate 
• 106-47-8 4-chloro-aniline 
• 96-34-4 methyl chloroacetate 
• 2028-74-2 p-chlorobenzenediazonium chloride 

Downstream Products

• 96722-73-5 1-(4-Chloro-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester 3-methyl ester 
• 89479-50-5 2-(4-chlorophenylhydrazono)-2,3-dihydro-4H-1,4-benzothiazin-3-one 
• 89479-45-8 methyl 2-(2-aminophenylthio)-2-(4-chlorophenylhydrazono)glyoxylate 
• 91075-77-3 1,6-Bis-(4-chloro-phenyl)-4,9-dithia-1,2,6,7-tetraaza-spiro[4.4]nona-2,7-diene-3,8-dicarboxylic acid dimethyl ester 
• 75998-63-9 Methyl-2-<2-(4-chlorphenyl)hydrazono>-2-hexylaminoacetat 
• 82417-48-9 Methyl-2-benzylidenhydrazino-2-(4-chlorphenylhydrazono)acetat 
• 76032-07-0 Methyl-2-<2-(4-chlorphenyl)hydrazono>-2-<3,5-bis(trifluormethyl)phenylamino>acetat 
• 54624-69-0 dimethyl 1-(4-chlorophenyl)-1H-pyrazole-3,4-dicarboxylate 
• 1353002-58-0 methyl (1-adamantylethynylsulfanyl)[(4-chlorophenyl)hydrazono]acetate 
• 932801-14-4 2-(1-adamantyl)methylene-4-(1-adamantyl)-[1,3]dithiol 
• 78241-07-3 3,6-Diacetyl-1,4-diphenyl-1H,4H-[1,2,4,5]tetrazine 
• 89894-21-3 1-(4-chlorophenyl)-1H-1,2,4-triazole 
• 57227-00-6 methyl 1-(3-chlorophenyl)-1H-1,2,4-triazole-3-carboxylate 
• 136514-99-3 5-(4-Chloro-phenyl)-2-methyl-6-pyridin-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

Abnormal activity of various N-methyl-d-aspartate receptor (NMDAR) subtypes has been implicated in a wide variety of neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. Imaging agents for PET and SPECT that target NMDARs in a subtype-selective fashion may enable better characterization of those disorders and enhance drug development. On the basis of a pyrazoline derivative that demonstrated neuroprotective effects in vivo, we synthesized a series of para-substituted analogues and measured their affinities to various NMDAR subtypes. Compounds 4a-c and 4e showed greater, nanomolar affinity for the GluN1/2A subtype versus GluN1/2B. Dicarbomethoxy (pro-drug) analogues of [124/125I]4d and [11C]4e (i.e., [124/125I]11d and [11C]11e) were generated and tested for NMDAR binding specificity in ex vivo autoradiography and brain biodistribution studies. Although NMDAR-specific binding could be demonstrated for [125I]11d and [11C]11e through autoradiography and biodistribution studies, imaging of neither [124I]11d nor [11C]11e could demonstrate brain penetration sufficient for detection by PET.

HETEROCYCLES FROM NITRILE IMINES. PART I. 1,2,3,4-TETRAHYDRO-1,2,4,5-TETRAZINES

The interaction between ketohydrazones and nitrile imines provides a new and direct synthetic route to 1,2,3,4-tetrahydro-1,2,4,5-tetrazines.Elemental analysis and spectral data are consistent with the assigned tetrazine ring system.

COPPER(II) IN ORGANIC SYNTHESIS. VI REACTION OF THE COPPER(II) ACETATE COMPLEX OF 1-METHYLISATIN-3-CHLOROPHENYLHYDRAZONE WITH DIMETHYL ACETYLENEDICARBOXYLATE.

The copper(II) complex of 1-methylisatin -3-p-chlorophenylhydrazone (2) reacted with dimethyl acetylenedicarboxylate (DMAD) in accordance to two reaction pathways.Oxidation performed by Cu(2+) gave 1-metyl-3-carbenindolin-2-one (12), trapped by DMAD to gi

Synthesis of New 2,5-Dihydro-1,2,3,5-Thiatriazole 1-Oxides and 3,4-Dihydro-2H-1,2,4,3-triazaphosphole 3-Oxides

Methyl 2-alkylamino- or 2-arylamino-2-(2-arylhydrazono)acetates 1 react with thionyl chloride in the absence of bases to give 5-alkyl- or 5-aryl-4-methoxycarbonyl-2,5-dihydro-1,2,3,5-thiatriazole 1-oxides 3.Reaction of alkylphosphonic dichlorides and 2 mo