Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester

Base Information

• Chemical Name: Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester
• CAS No.: 62465-90-1
• Molecular Formula: C9H8 Cl2 N2 O2
• Molecular Weight: 247.081
• Hs Code.: 2928000090
• Mol file: 62465-90-1.mol

Synonyms:62465-90-1;Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester;methyl chloro[(4-chlorophenyl)hydrazono]acetate;methyl (2Z)-2-chloro-2-[(4-chlorophenyl)hydrazinylidene]acetate;methyl-chloro[(4-chlorophenyl)hydrazono]acetate;METHYLCHLORO[(4-CHLOROPHENYL)HYDRAZONO] ACETATE;C9-H8-Cl2-N2-O2;MFCD03175036;AKOS024288046;CS-0363215;AP-501/41004070;methyl (2Z)-chloro[(4-chlorophenyl)hydrazono]ethanoate;Methyl (Z)-2-chloro-2-(2-(4-chlorophenyl)hydrazono)acetate;METHYL (2Z)-2-CHLORO-2-[2-(4-CHLOROPHENYL)HYDRAZIN-1-YLIDENE]ACETATE

Chemical Property of Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 149 °C
• PSA: 50.69000
• Density: 1.37 g/cm³
• LogP: 2.55020
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 245.9962829
• Heavy Atom Count: 15
• Complexity: 251

Purity/Quality:

99% ^*data from raw suppliers

Methyl chloro[(4-chlorophenyl)hydrazono]acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(=NNC1=CC=C(C=C1)Cl)Cl
• Isomeric SMILES: COC(=O)/C(=N/NC1=CC=C(C=C1)Cl)/Cl

Technology Process of Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester

There total 3 articles about Acetic acid, chloro((4-chlorophenyl)hydrazono)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-chloroacetoacetate (4755-81-1,935731-92-3) + 4-chloro-aniline (106-47-8) → methyl (N-(4-chlorophenyl)hydrazono)chloroacetate (62465-90-1)

Guidance literature:

With hydrogenchloride; sodium acetate; sodium nitrite; In water; 1) 8 deg C, 2) MeOH, 6 deg C (33 percent NaOH, pH= 4.5);

Reference yield:

methyl 2-chloroacetoacetate (4755-81-1,935731-92-3) + p-chlorobenzenediazonium chloride (2028-74-2) → methyl (N-(4-chlorophenyl)hydrazono)chloroacetate (62465-90-1)

Guidance literature:

In pyridine; water; at 0 - 5 ℃; Yield given;

Reference yield:

4-chloro-aniline (106-47-8) + methyl chloroacetate (96-34-4) → methyl (N-(4-chlorophenyl)hydrazono)chloroacetate (62465-90-1)

Guidance literature:

With sodium acetate; hydrogen cation; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, 0 to 50 deg C; 2.) H₂O;

DOI:10.1016/S0040-4020(01)86889-7

upstream raw materials:

methyl 2-chloroacetoacetate

p-chlorobenzenediazonium chloride

4-chloro-aniline

methyl chloroacetate

Downstream raw materials:

dimethyl 1-(4-chlorophenyl)-1H-pyrazole-3,4-dicarboxylate

methyl 1-(4-chlorophenyl)-3a,4,11,11a-tetrahydro-4,11-epoxy-1H-naphtho[2,3-f]indazole-3-carboxylate

methyl 1-(4-chlorophenyl)-1H-naphtho[2,3-f]indazole-3-carboxylate

5-(4-Chloro-phenyl)-2-methyl-6-pyridin-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester