62467-76-9Relevant academic research and scientific papers
Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines
Song, Ming-Xia,Zhang, Chun-Bo,Deng, Xian-Qing,Sun, Zhi-Gang,Quan, Zhe-Shan
experimental part, p. 769 - 773 (2012/04/18)
Various 6-phenyl-7H-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazine derivatives (3a-3n) were designed keeping in view the wide bioactivities of 1, 2, 4-triazoles and their fused heterocyclic derivatives. All target compounds 3a-3n, characterized by IR, 1H-NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that most of the compounds displayed some degree of anticonvulsant activity. Among them, 6-(4-chlorophenyl)-7H-[1,2, 4]triazolo[3, 4-b][1,3,4]thiadiazine (3h) was the most promising compound with an ED50 value of 40.9 mg/kg and a PI value of 6.5.
CONDENSED SYSTEMS BASED ON 4-AMINO-3-MERCAPTO-1,2,4-TRIAZOLE
Kolos, N. N.,Orlov, V. D.,Slobodina, E. K.,Yur'eva, E. Yu.,Korshunov, S. P.,Tue, Zyong van
, p. 222 - 227 (2007/10/02)
1,2,4-Triazolo-1,3,4-thiadiazines, hydrazones, and β-thio adducts were obtained by reactions of 4-amino-3-mercapto-1,2,4-triazole with ω-bromoacetophenones, aldehydes, and α,β-unsaturated ketones.Conditions that promote the cyclocondensation of the
