624727-28-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 624727-27-1 (+)-(R)-ethyl 5-(4-methoxybenzyloxy)-3-hydroxypentanoate 
• 624727-26-0 ethyl 5-[(4-methoxybenzyl)oxy]-3-oxopentanoate 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 937800-24-3 C₂₄H₄₂O₄Si₂ 
• 937800-12-9 (5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-yn-3-ol 
• 937800-25-4 C₂₃H₃₈O₄Si 
• 937800-16-3 (7S,2E,4Z)-7-(tert-butyldimethylsilyloxy)-9-(4-methoxybenzyloxy)nona-2,4-dienal 
• 937800-19-6 (5S,6E,8Z,11S)-5-allyl-11-(2-(4-methoxybenzyloxy)ethyl)-2,2,13,13,14,14-hexamethyl-3,3-diphenyl-4,12-dioxa-3,13-disilapentadeca-6,8-diene 
• 937800-21-0 (3S,5Z,7E,9S)-3-(tert-butyldimethylsilyloxy)-9-(tert-butyldiphenylsilyloxy)dodeca-5,7,11-trienal 
• 123-11-5 4-methoxy-benzaldehyde 
• 624727-36-2 methyl 2-[(2E,5S,6R,8R)-8-{[tert-butyl(dimethyl)silyl]oxy}-10-[(4-methoxybenzyl)oxy]-6-(methoxymethoxy)-5-methyldec-2-enyl]-6-methoxybenzoate 
• 624727-30-6 (4S)-4-benzyl-3-[(2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-7-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methylheptanoyl]-1,3-oxazolidin-2-one 
• 624727-29-3 (4S)-4-benzyl-3-{(2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-hydroxy-7-[(4-methoxybenzyl)oxy]-2-methylheptanoyl}-1,3-oxazolidin-2-one 
• 624727-34-0 (2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-7-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methylheptyl 4-methylbenzenesulfonate 
• 624727-41-9 2-[(2E,5S,6R,8R)-8-hydroxy-10-[(4-methoxybenzyl)oxy]-6-(methoxymethoxy)-5-methyldec-2-enyl]-6-methoxybenzoic acid 
• 624727-39-5 methyl 2-[(2E,5S,6R,8R)-8-hydroxy-10-[(4-methoxybenzyl)oxy]-6-(methoxymethoxy)-5-methyldec-2-enyl]-6-methoxybenzoate 
• 624727-32-8 (2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-7-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methylheptan-1-ol 

Relevant academic research and scientific papers

Synthetic studies on macrolactin A: Construction of C4-C24 fragment

(Chemical Equation Presented) The preparation of the C4-C24 fragment of the macrolactin A is described. The adopted synthetic strategy involves two isomerizations to selectively construct the (8E,10Z) and (16E,18E) dienes, using a sequential Claisen rearrangement/allene isomerization and a Ph 3P-catalyzed isomerization of an yne-one, respectively.

A formal total synthesis of the salicylihalamides

The synthesis of the macrolactone 23 is described. The synthesis features a diastereoselective hydroboration of the chiral alkene 17 followed by a Suzuki cross-coupling reaction with the benzoate 5. The resulting seco acid 21 was converted to the macrolac