624729-74-4

Usage

Uses

Used in Pharmaceutical Industry:
8-Amino-3,4-dihydro-1H-naphthalen-2-one is used as an intermediate in the production of various pharmaceuticals for its ability to be a key component in the synthesis of medicinal compounds.
Used in Organic Chemistry:
8-Amino-3,4-dihydro-1H-naphthalen-2-one is used as a valuable building block in organic chemistry for its versatility in forming other chemical compounds, contributing to the development of new materials and substances.

InChI:InChI=1/C10H11NO/c11-10-3-1-2-7-4-5-8(12)6-9(7)10/h1-3H,4-6,11H2

Upstream product

• 624729-63-1 (7-ethoxy-naphthalen-1-yl)-carbamic acid t-butyl ester 
• 1254716-28-3 tert-butyl N-(7-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate 
• 624729-65-3 (7-ethoxy-5,8-dihydronaphthalen-1-yl)amine 

Downstream Products

• 624729-66-4 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 
• 851266-39-2 8-(benzylamino)-3,4-dihydronaphthalen-2(1H)-one 
• 851266-44-9 benzyl(7-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate 
• 851266-40-5 N-benzyl-7-methylene-5,6,7,8-tetrahydro-naphthalen-1-amine 
• 851266-46-1 benzyl [7-(hydroxymethyl)-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate 
• 624729-72-2 (7-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl)-carbamic acid phenyl ester 
• 851266-41-6 N-benzyl-7-methyl-5,6,7,8-tetrahydronaphthalen-1-amine 
• 851266-45-0 benzyl[(7E)-7-(methoxymethylene)-5,6,7,8-tetrahydronaphthalen-1-yl]carbamate 
• 710954-91-9 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-[3-piperidin-1-yl-4-(trifluoromethyl)benzyl]urea 
• 711016-23-8 2-(3-bromophenyl)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 711016-20-5 2-biphenyl-3-yl-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 711015-38-2 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N'-(4'-methylbiphenyl-3-yl)urea 
• 711016-15-8 3',4'-difluoro-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)biphenyl-4-carboxamide 
• 711016-22-7 N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-4-iodobenzamide 

Relevant academic research and scientific papers

Tetrahydro-naphthols as orally available TRPV1 inhibitors

Starting from a naphthol-based lead series with low oral bioavailability, we have identified potent TRPV1 antagonists with oral bioavailability in rats. These compounds emerged from SAR studies aimed at replacing the lead's phenol structure whilst maintai

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

Vanilloid receptor (VR) inhibitors for treatment of Human Immunodeficiency Virus (HIV)-mediated pain states

The invention relates to the application of Vanilloid receptor (VR) 1 inhibitors for drug development and for the treatment of HIV-mediated neuropathies and neuropathic pain states. Further, the inventor identified a novel signaling cascade connecting the

TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES

This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -

HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES

This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excelle

TETRAHYDRO-NAPHTHALENE DERIVATIVES AS VANILLOID RECEPTOR ANTAGONISTS

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago

TETRAHYDRO-NAPHTHALENE DERIVATIVES

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago

HYDROXY TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antago