62476-15-7

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-(ETHYLAMINO)ANILINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Dye Industry:
In the dye industry, 5-CHLORO-2-(ETHYLAMINO)ANILINE is utilized as a precursor in the production of dyes, enabling the creation of a diverse range of colorants for various applications.
Used in Agrochemical Industry:
5-CHLORO-2-(ETHYLAMINO)ANILINE is employed as a chemical intermediate in the formulation of agrochemicals, playing a crucial role in the development of effective pesticides and other agricultural products.
Used in Organic Synthesis Processes:
5-CHLORO-2-(ETHYLAMINO)ANILINE is used as a versatile building block in organic synthesis processes, facilitating the creation of a wide array of chemical products and contributing to advancements in the field of chemistry.

InChI:InChI=1/C8H11ClN2/c1-2-11-8-4-3-6(9)5-7(8)10/h3-5,11H,2,10H2,1H3

Upstream product

• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 28491-95-4 N-ethyl-4-chloro-2-nitro-aniline 

Downstream Products

• 2818-76-0 5-chloro-1-ethyl-2-methyl-1H-benzoimidazole 
• 69015-51-6 1-ethyl-5-chloro-1H-benzimidazole 
• 89659-75-6 [5-Chloro-2-(ethoxycarbonyl-ethyl-amino)-phenyl]-carbamic acid ethyl ester 
• 1049798-81-3 1-ethyl-5-chloro-2-(3,4-dichloroanilino)-1H-benzimidazole 
• 22316-25-2 7-chloro-1-ethyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 1267634-99-0 C₂₁H₂₂ClN₃O₃ 
• 343245-33-0 C₂₂H₁₈Cl₃N₅ 

Relevant academic research and scientific papers

Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivity

A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.