28491-95-4

Basic information

• Product Name: N-ETHYL 4-CHLORO-2-NITROANILINE
• Synonyms: N-ETHYL 4-CHLORO-2-NITROANILINE;BUTTPARK 45\09-54;N1-ethyl-4-chloro-2-nitroaniline;4-chloro-N-ethyl-2-nitroaniline
• CAS NO: 28491-95-4
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.62
• EINECS: 249-055-4
• Mol File: 28491-95-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 328.9°Cat760mmHg
• Flash Point: 152.7°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.613
• PKA: -1.62±0.50(Predicted)
• CAS DataBase Reference: N-ETHYL 4-CHLORO-2-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYL 4-CHLORO-2-NITROANILINE(28491-95-4)
• EPA Substance Registry System: N-ETHYL 4-CHLORO-2-NITROANILINE(28491-95-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 28491-95-4(Hazardous Substances Data)

Usage

General Description

N-ETHYL 4-CHLORO-2-NITROANILINE is a chemical compound with the molecular formula C8H8ClN2O2. It is a yellow solid that is commonly used as an intermediate in the production of dyes and pigments. N-ETHYL 4-CHLORO-2-NITROANILINE is primarily used in the manufacturing of azo dyes, which are widely utilized in textile and leather industries. N-ETHYL 4-CHLORO-2-NITROANILINE is also used in the production of pharmaceuticals and agrochemicals. It is important to handle this chemical with care, as it is classified as harmful if swallowed, in contact with skin, or if inhaled, and can cause irritation to the skin and eyes.

InChI:InChI=1/C8H9ClN2O2/c1-2-10-7-4-3-6(9)5-8(7)11(12)13/h3-5,10H,2H2,1H3

Upstream product

• 2873-89-4 4-chloro-N,N-diethylaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 75-04-7 ethylamine 
• 557-66-4 ethanamine hydrochloride 
• 89-63-4 4-Chloro-2-nitroaniline 
• 106-47-8 4-chloro-aniline 
• 86309-90-2 N-(4-Chloro-2-nitrophenyl)diethylamine 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 86309-91-3 (4-Chloro-2-nitrophenyl)ethylnitrosamine 
• 13519-85-2 4-chloro-N-ethyl-N-methylaniline 
• 89-61-2 2,5-dichloronitrobenzene 

Downstream Products

• 1267634-99-0 C₂₁H₂₂ClN₃O₃ 
• 22316-25-2 7-chloro-1-ethyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 69015-51-6 1-ethyl-5-chloro-1H-benzimidazole 
• 62476-15-7 4-chloro-N¹-ethylbenzene-1,2-diamine 

Relevant articles and documents

A Six-Crossing Doubly Interlocked [2]Catenane with Twisted Rings, and a Molecular Granny Knot

A molecular 632 link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 31#31 granny knot (a composite knot made up of two trefoil tangles of the same handedness) were constructed by ring-closing olefin metathesis of an iron(II)-coordinated 2×2 interwoven grid. The connections were directed by pendant phenyl groups to be between proximal ligand ends on the same faces of the grid. The 632 link was separated from the topoisomeric granny knot by recycling size-exclusion chromatography. The identity of each topoisomer was determined by tandem mass spectrometry and the structure of the 632 link confirmed by X-ray crystallography, which revealed two 82-membered macrocycles, each in figure-of-eight conformations, linked through both pairs of loops.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.