62486-64-0

Upstream product

• 99-91-2 para-chloroacetophenone 
• 122-51-0 orthoformic acid triethyl ester 
• 64-17-5 ethanol 

Downstream Products

• 109482-05-5 (Z)-3-(4-Chloro-phenyl)-2-trimethylsilanylmethyl-but-2-enoic acid ethyl ester 
• 10359-10-1 2-(4-chlorophenyl)-2-methyl-1,3-dithiane 
• 1138700-32-9 N-1-(4-chlorophenyl)ethylidene-O,O-diethylthiophosphoramide 
• 1138700-38-5 N-1-(4-chlorophenyl)ethylidene-diphenylthiophosphinamide 

Relevant academic research and scientific papers

Acid-free, organocatalytic acetalization

The acid-free, organocatalytic acetalization of various aldehydes and ketones with N,N′-bis[3,5-bis(trifluoromethyl)phenyl]thiourea is presented. The neutral, double hydrogen bonding thiourea catalyst can be used at very low loadings of 0.01-1 mol% at room temperature to furnish the respective acetals in 65-99% yield at turnover frequencies around 600 h-1. Acid-labile TBDMS-protected as well as unsaturated aldehydes can be converted efficiently into their acetals utilizing this very mild and highly practical method.

A highly efficient and chemoselective method for acetalization of carbonyl compounds catalyzed by TiO2/SO42- solid superacid

Various types of aldehydes and ketones could be converted to their corresponding diethyl acetals with triethylorthoformate in the presence of TiO2/SO42- solid superacid in good to excellent yield under mild reaction conditions.

2,4,4,6-Tetrabromo-2,5-cyclohexadienone (TABCO) as a versatile, efficient, and chemoselective catalyst for the acetalization and transacetalization of carbonyl compounds, the preparation of acetonides from epoxides and acylals (1,1-diacetates) from aldehydes

The efficient and chemoselective preparation of acetals and ketals from carbonyl compounds, transacetalization reactions, the conversion of epoxides to acetonides, and the preparation of acylals from aldehydes in the presence of catalytic amounts of 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TABCO) are described.

W-bromosuccinimide (NBS) as a powerful and chemoselective catalyst for acetalization of carbonyl compounds under almost neutral reaction conditions

Highly efficient and mild acetalization of various types of carbonyl compounds was achieved using NBS under almost neutral reaction conditions. Due to the neutrality of the medium this method is especially useful for the protection of acid sensitive substrates. Thieme Stuttgart.

2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as a highly efficient and mild catalyst for diethyl acetalization of carbonyl compounds

Various types of structurally different carbonyl compounds in the presence of ethyl orthoformate (EtO)3CH could be efficiently converted to their diethyl acetals by using a catalytic amount (1-3 mol%) of DDQ under mild reaction conditions.

18O-Isotope Effect in 13C Nuclear Magnetic Resonance Spectroscopy. 5 - Substituent Group Electronic Effects in Substituted Acetophenones

A series of para- and meta-substituted acetophenones were prpared which were highly labeled with 18O at the carbonyl function.The natural abundance 13C NMR spectra of the compounds were recorded and the 18O-isotope-induced shifts of the carbonyl carbon we