10359-10-1

Upstream product

• 109-80-8 1.3-propanedithiol 
• 36881-02-4 2-(4-chlorophenyl)-2-methyl-1,3-dioxolane 
• 62486-64-0 4-chloroacetophenone diethyl acetal 
• 99-91-2 para-chloroacetophenone 
• 55727-23-6 3‐(1,3-dithiane-2-yl)pentane-2,4-dione 
• 682360-46-9 2-(1,3-dithian-2-ylidene)-3-oxobutanoic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 57529-04-1 2-chloro-1,3-dithiane 
• 461024-59-9 2-(1,3-dithian-2-ylidene)malonic acid 
• 67-56-1 methanol 

Downstream Products

• 99-91-2 para-chloroacetophenone 
• 861838-89-3 2-(4-chlorophenyl)-6,7-dihydro-5H-1,4-dithiepine 
• 10359-12-3 2-(4-chloro-phenyl)-2-methyl-[1,3]dioxane 

Relevant academic research and scientific papers

Tungsten hexachloride (WCl6) as an efficient catalyst for chemoselective dithioacetalization of carbonyl compounds and transthioacetalization of acetals

A variety of aldehydes, ketones and O,O-acetals were efficiently converted to the corresponding 1,3-dithianes and 1,3-dithiolanes by using catalytic amounts of tungsten hexachloride (WCl6) in CH2Cl2 under mild conditions.

Ni-NiO heterojunctions: a versatile nanocatalyst for regioselective halogenation and oxidative esterification of aromatics

Herein, we report a facile method for the synthesis of Ni-NiO heterojunction nanoparticles, which we utilized for the nuclear halogenation reaction of phenol and substituted phenols usingN-bromosuccinimide (NBS). A remarkablepara-selectivity was achieved for the halogenated products under semi-aqueous conditions. Interestingly, blocking of thepara-position of phenol offeredortho-selective halogenation. In addition, the Ni-NiO nanoparticles catalyzed the oxidative esterification of carbonyl compounds with alcohol, diol or dithiol in the presence of a catalytic amount of NBS. It was observed that the aromatic carbonyls substituted with an electron-donating group favoured nuclear halogenation, whereas an electron-withdrawing group substitution in carbonyl compounds facilitated the oxidation reaction. In addition, the catalyst was magnetically separated and recycled 10 times. The tuned electronic structure at the Ni-NiO heterojunction controlled selectivity and activity as no suchpara-selectivity was observed with commercially available NiO or Ni nanoparticles.

An expedient carbon–sulfur bond formation explored through the cellulose sulfonic acid (CSA) catalyzed dithioacetal protection of carbonyl compounds

A facile carbon–sulfur bond formation was observed through the cellulose sulfonic acid (CSA) catalyzed dithioacetal protection of carbonyl compounds. In a preliminary study, the synthesis and characterization of functionalized bio-polymer, cellulose sulph

Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN

A mild process using a combination of TMSCl and NaI in acetonitrile is used to regenerate carbonyl compounds from a variety of dithiane and dithiolane derivatives. This easy to handle and inexpensive protocol is also efficient to deprotect oxygenated and mixed acetals as 1,3-dioxanes, 1,3-dioxolanes and 1,3-oxathianes quantitatively. As a possible extension of this method, it was also shown that nitrogenated substrates such as hydrazones, N-tosylhydrazones, and ketimines reacted well under these conditions to give the expected ketones in high yields. The methodology proposed herein is a good alternative to the existing methods since it does not use metals, oxidants, reducing agents, acidic or basic media, and keto-products were obtained in high to excellent yields.

Alcohol-mediated direct dithioacetalization of alkynes with 2-chloro-1,3-dithiane for the synthesis of Markovnikov dithianes

An alcohol-mediated dithioacetalization process that gains direct access to the corresponding Markovnikov-selective 1,3-dithianes using unactivated alkynes and nonthiolic/odorless 2-chloro-1,3-dithiane in a highly efficient manner has been developed. This methodology has the advantage of having mild reaction conditions, and the dithioacetalization process gives good to excellent yields with high Markovnikov-selectivity.

A substituted -1,3-dithiane-preparation method of compound

The invention discloses a method for preparing substituted-1,3-dithiane compounds. The method comprises the following steps: 1. with 1,2-dichloroethane or dichloromethane as a solvent, stirring to react 2-chlor-1,3-dithiane with alkynes with a general formula I for 1-24 hours at a temperature condition of 45-80 DEG C in the presence of an acid medium and alcoholic compounds; 2. removing the solvent in the reaction system by rotary evaporation after the reaction, and separating and purifying the residues by column chromatography to obtain substituted-1,3-dithiane compounds with a general formula II. According to the method disclosed by the invention, the 2-chlor-1,3-dithiane directly reacts with different types of alkynes, thereby not only avoiding the defects of foul smell, strong volatility and toxicity when 1,3-propanedithiol is used, but also being safe in operation and environmental friendly, and the method has the advantages of mild reaction conditions, simple operation, high yield, etc.

Aluminum hydrogen sulfate [Al(HSO4)3] as an efficient catalyst for the preparation of thioacetals

Aluminum hydrogen sulfate, as a heterogeneous solid acid catalyst, has been used for the mild conversion of carbonyl compounds to their thioacetals using 1,2- and 1,3-dithiol under ambient conditions with short reaction times in high to excellent yield in

Synthesis and deprotection of 1,3-Dithianes and 1,3-Dithiolanes by polyphosphoric acid

A simply, mild and efficient method for the deprotection of 1,3-dithianes and 1,3-dithiolanes to their corresponding carbonyl compounds using a mixture of polyphosphoric acid and acetic acid at 20-45 °C is reported.

Silica-PCl5: A novel heterogenous catalyst for simple and efficient chemoselective protection of carbonyl compounds

A simple, efficient and environmentally benign procedure has been developed for chemoselective protection of carbonyl compounds using the newly developed heterogeneous catalyst: Silica-PCl5. A variety of aldehydes and ketones were efficiently c

Efficient method for thioacetalization of carbonyl compounds in the presence of a catalytic amount of benzyltriphenylphosphonium tribromide (BTPTB) under solvent-free conditions

A variety of carbonyl compounds have been successfully converted to the corresponding thioacetal derivatives in good to excellent yields on reaction of carbonyl compounds with 1,2-ethanedithiole, 1,3-propanedithiol, and ethylthiol in the presence of a cat