62495-71-0

Basic information

• Product Name: Thiourea, N-(2-methyl-4-oxo-3(4H)-quinazolinyl)-N'-phenyl-
• CAS NO: 62495-71-0
• Molecular Formula: C16H14N4OS
• Molecular Weight: 310.379
• Mol File: 62495-71-0.mol

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(2-methyl-4-oxo-3(4H)-quinazolinyl)-N'-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(2-methyl-4-oxo-3(4H)-quinazolinyl)-N'-phenyl-(62495-71-0)
• EPA Substance Registry System: Thiourea, N-(2-methyl-4-oxo-3(4H)-quinazolinyl)-N'-phenyl-(62495-71-0)

Safety Data

• Hazardous Substances Data: 62495-71-0(Hazardous Substances Data)

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 1898-06-2 3-amino-2-methyl-4-oxoquinazoline 
• 103-72-0 phenyl isothiocyanate 
• 118-92-3 anthranilic acid 
• 54789-69-4 2-methyl-4H-benzo[1,3]oxazin-4-one 

Downstream Products

• 154548-15-9 2-methyl-3-(3-phenyl-5-carboxymethyl-4-oxothiazolidine-2-ylidene)amino-4(3H)-quinazolinone 
• 98166-39-3 2-methyl-3-(3-phenyl-4-oxothiazolidin-2-ylidene)amino-4(3H)-quinazolinone 
• 1394357-30-2 2-methyl-3-(6-methyl-4-oxo-3-phenyl-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)quinazolin-4(3H)-one 
• 1394357-31-3 3-(4,6-dimethyl-3-phenyl-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methylquinazolin-4(3H)-one 
• 1394357-32-4 3-(4-amino-3-phenylthiazol-2(3H)-ylideneamino)-2-methylquinazolin-4(3H)-one 
• 117054-65-6 5-[(2,4-Dichloro-phenylamino)-methyl]-1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-3-phenyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-61-2 5-[(2-Chloro-phenylamino)-methyl]-1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-3-phenyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-53-2 Hexahydro-1-<2-methyl-4(3H)-oxo-3-quinazolinyl>-3-phenyl-5-phenylaminomethyl-2-thioxo-pyrimidine-4,6-dione 
• 117054-49-6 5-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-3-phenyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-39-4 1-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-3-phenyl-5-[1-phenyl-meth-(Z)-ylidene]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 117054-29-2 1-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-3-phenyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 154548-14-8 2-methyl-3-(3-phenyl-5-methoxycarbonylmethine-4-oxothiazolidin-2-ylidene)amino-4(3H)-quinazolinone 
• 113124-48-4 2-methyl-3-(3,4-diphenyl-2,3-dihydrothiazol-2-ylidene)amino-4(3H)-quinazolinone 
• 98166-39-3 2-Methyl-3-(4-oxo-3-phenyl-thiazolidine-2-ylidenamino)-4(3H)-quinazolinone 

Relevant articles and documents

Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitors

Four novel series of 1-substituted-3-(2-methyl-4-oxo-4H-quinazolin-3-yl) urea and/or thiourea IIIa-c, 4-substituted-N-(2-methyl-4-oxo-4H-quinazolin-3-yl) benzene sulfonamide VIa-c and their NO-hybrid molecules as nitrate esters Va-c and VIIIa-c have been

Antitumor and antileishmanial evaluation of novel heterocycles derived from quinazoline scaffold: A molecular modeling approach

Novel thiazole, pyrimidine and benzylidene derivatives derived from quinazoline scaffold have been synthesized. The antitumor evaluation of the newly synthesized products against three cancer cell lines namely breast adenocarcinoma (MCF-7), non-small cell

Synthesis of some 2-methyl-3-(arylthiocarbamido) quinazol-4-ones and 2-methyl-3-(arylidencarboxamido) quinazol-4-ones as potential antimicrobial agents

Some quinazolone derivatives of 2-methyl-3-(arylthiocarbamido) quinazol-4-ones (2) and 2-methyl-3(arylidencarboxamido) quinazol-4-ones (3) have been synthesized and assayed for their possible antibacterial activity against Bacillus subtilis, Bacillus cereus, Salmonella aureus, Salmonella lutae and antiviral activity against Gomphrena mosaic virus. Some of these compounds show notable activity.

Pharmacological studies of some 2-methyl-3-(arylthio-carbamido) quinazol-4-ones and 2-methyl-3-(aryliden-carboxamido) quinazol-4-ones

Some quinazolone derivatives of 2-methyl-3-(arylthio-carbamido)quinazol-4-ones 2 and 2-methyl-3-(aryliden-carboxamido) quinazol-4-ones 3 have been synthesised and assayed for their possible antibacterial activity against Bacillus subtilis, Bacillus cereus, Solmonella aureus, Solmonella lutae and antiviral activity against Gomphrena mosaic virus. Some of these compounds show notable activity.

Synthesis ans Biological Evaluation of Some New Fused Quinzoline Derivatives

Some new fused quinazoline derivatives have been prepared by reacting 3-N-acyl / aroylamino quinazolin-4(3)-ones (2) with different nucleophilic reagents.The structural assignments of all the new products were based on elemental analysis and chemical and spectroscopic data, and somw of the products have been screened for their antimicrobial activity. - Key Words: synthesis; biological; fused quinazolines

Synthesis of substituted quinazolone derivatives as potential anti-HIV agents (part III)

Several 1-[2-phenyl-4(4H)-oxo-3-quinazolinyl]-2-methyl-4-arylidine -5-oxo-imidazolines (Va-1), 2-phenyl-3-(aroyl amino)-4(4H)-oxo quinazolines (Vla-I) and N1-2-methyl-4(4H)-oxo-3-quinazolinyl-N2-aryl-thioureas (Vlla-k), have been synthesised and tested for anti-HIV activity. The structures of these compounds have been established on the basis of elemental analysis and spectral data.

Synthesis and reactions of 3-amino-2-methyl-4(3H)-quinazolinone derivatives

3-Amino-2-methyl-4(3H)-quinazoline (2) has been synthesized by treating 2-methylbenzoxazinone (1) with hydrazine hydrate.Reaction of quinazolinone (2) with phenyl isothiocyanate and phenyl isocyanate furnish the corresponding aminocarbothiamide and aminocarbamide derivatives (3 and 5), respectively, which on reaction with malonic acid in acetyl chloride afford thiobarbituric and barbituric acid derivatives (4 and 6), respectively.Behaviour of compound 5 towards different aldehydes, ketones and imides have been investigated.

Synthesis and anticonvulsant properties of some novel quinazolinone thiazolidine and 4-thiazolidone derivatives

A series of quinazolinone thiazolidine and 4-thiazolidone derivatives were prepared. The structure of the isolated products have been confirmed by elemental analyses, spectroscopic data and ambiguous synthesis in certain cases. Some of these compounds wer

Synthesis of Quinazolinylpyrimidinediones and Their Anti-inflammatory Activity

Hexahydro-1--3-aryl-2-thioxopyrimidine-4,6-diones (IV) have been prepared and converted into hexahydro-1--3-aryl-5-benzyliden-2-thioxopyrimidine-4,6-diones (V) and hexahydro-1-2-alkyl-4(