62498-74-2Relevant academic research and scientific papers
High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry
Cooks, R. Graham,Ferreira, Christina R.,Li, Yangjie,Logsdon, David L.,Paschoal Sobreira, Tiago Jose,Thompson, David H.
supporting information, p. 1647 - 1657 (2020/10/26)
This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.
Dipicolylamine coupled rhodamine dyes: New clefts for highly selective naked eye sensing of Cu2+ and CN- ions
Ghosh, Kumaresh,Tarafdar, Debojyoti,Majumdar, Anupam,Daniliuc, Constantin G.,Samadder, Asmita,Khuda-Bukhsh, Anisur Rahman
, p. 47802 - 47812 (2016/06/06)
The dipicolylamine (DPA) motif which is known as a binder of Zn(ii) ions, has been utilized in devising rhodamine labelled compounds 1 and 2. Compound 1 acts as a FRET sensor and shows excellent selectivity for Cu(ii) ions over a series of other cations in CH3CN/H2O by exhibiting a colour change (colourless to pink) of the solution. The spectral and colour changes are recovered in the presence of CN- ions and thus, the ensemble 1·Cu2+ in CH3CN/H2O is established as the medium for selective detection of CN- ions. In contrast, the modified compound 2 with the dipicolylamine motif as the principal binding site has been established as the colorimetric sensor of Cu(ii) ions and the fluorometric sensor of Hg(ii), Zn(ii) and Cd(ii) ions. Both the compounds 1 and 2 are cell permeable and are successfully employed for the detection of intercellular metal ions through bright field and fluorescence imaging.
JOINT EFFECT OF STRUCTURAL FACTORS, TEMPERATURE, AND POLARITY OF THE MEDIUM ON RATE OF REACTIONS OF BENZYL BROMIDES WITH BUTYLAMINE. MANY-PARAMETER CORRELATIONS
Shpan'ko, I. V.,Serebryakov, I. M.,Korostylev, A. P.
, p. 1224 - 1230 (2007/10/02)
The rates of the reactions of benzyl bromides with butylamine were measured in nitrobenzene, chlorobenzene, and their mixtures at 40, 50, and 60 deg C and also in a 1:1 mixture of chlorobenzene with cyclohexane at 40 deg C.The effects of the variable factors (the structure of benzyl bromides, temperature, polarity of the medium) on the process rate were evaluated separately and in pairs and the joint effect of all three factors was also determined.The effect of the structure of the substrate and the polarity of the medium on the nature of the transition states in the reactions is discussed.
