625091-62-5Relevant academic research and scientific papers
Palladium-catalyzed synthesis of 2-aminoindoles by a heteroanulation reaction
Witulski, Bernhard,Alayrac, Carole,Tevzadze-Saeftel, Lali
, p. 4257 - 4260 (2007/10/03)
Chelates are the key: A conceptually novel indole ring forming reaction through heteroanulation is available through the palladium-catalyzed reaction of N-alkenylanilides with primary or secondary amines. The key feature is the formation of an unprecedented σ,π-chelated palladium species (see scheme); nitrogen nucleophiles can add to the activated alkyne unit of this species to form the indole skeleton. (X = I, Br; HNR2R3= prim. or sec. amine; Ts =tosyl.).
