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3β,5α-Tetrahydroaldosterone (THAldo) is a naturally occurring metabolite of aldosterone, a hormone that plays a crucial role in regulating blood pressure and electrolyte balance. It is formed through the reduction of aldosterone in the liver and kidneys, and its primary function is to maintain the body's fluid and sodium balance. THAldo has been found to have a longer half-life than aldosterone, which allows for a more sustained effect on the body. Research has shown that it may also have potential therapeutic applications in the treatment of certain conditions, such as heart failure and hypertension, due to its ability to modulate the renin-angiotensin-aldosterone system. However, further studies are needed to fully understand the mechanisms of action and potential clinical implications of this chemical.

6251-41-8

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6251-41-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6251-41-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,5 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6251-41:
(6*6)+(5*2)+(4*5)+(3*1)+(2*4)+(1*1)=78
78 % 10 = 8
So 6251-41-8 is a valid CAS Registry Number.

6251-41-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3beta,5alpha-Tetrahydroaldosterone (hemiacetal form)

1.2 Other means of identification

Product number -
Other names 3β-Hydroxy-5α-(4,5)-tetrahydro-aldosteron

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6251-41-8 SDS

6251-41-8Downstream Products

6251-41-8Relevant academic research and scientific papers

18-Substituted Steroids. Part 13. Improved Preparation of the Metabolites of Aldosterone Reduced in Ring A

Kirk, David N.,Rajagopalan, Maruthiandan S.

, p. 1343 - 1346 (2007/10/02)

Protection of the side-chain of aldosterone as the 21-t-butyldimethylsilyl (TBDMS) ether was also found to mask the 20-oxo function, by effectively locking the tautomeric structure of aldosterone into its 11,18:18,20-diepoxy form.Catalytic hydrogenation of aldosterone 21-TBDMS ether gave the 5α- or the 5β-dihydro derivative depending on the choice of solvent.Subsequent reduction of the carbonyl group at C-3, with either 'K-selectride' to form the 3-axial alcohol or lithium tri-t-butoxyaluminium hydride to form the 3-equatorial alcohol, was found to proceed without attack on the side-chain, to give convenient routes to the four isomeric tetrahydroaldosterones.

18-Substituted Steroids. Part 7. Synthesis and Structure of 11β,18-Epoxy-3α,18,21-trihydroxy-5β-pregnan-20-one (3α,5β-Tetrahydroaldosterone)

Kirk, David N.,Miller, Barry W.

, p. 2818 - 2829 (2007/10/02)

3α,5β-Tetrahydroaldosterone (1) has been prepared from 21-deoxy-3α,5β-tetrahydroaldosterone 18-methyl ether 3-(tetrahydropyran-2-yl) ether (6).Kinetically controlled enolisation with lithium di-isopropylamide followed by treatment with chlorotrimethylsilane generated specifically the Δ20(21)-trimethylsilyl enol ether (17), which reacted with 3-chloroperbenzoic acid to give the 18-methyl ether-21-alcohol (18), which was converted into its 21-acetate (27).Acid solvolysis of the protecting groups at C-3 and -18 with anhydrous acetic acid, followed by mild alkaline hydrolysis with sodium hydrogencarbonate afforded 3α,5β-tetrahydroaldosterone (1) in 26percent overall yield.

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