625111-32-2Relevant articles and documents
Synthesis of locked nucleic acid derivatives
-
Page 11, (2008/06/13)
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising
Improved synthesis of 2′-amino-LNA
Christensen, Signe M.,Rosenbohm, Christoph,Sorensen, Mads,Larsen, Lotte-Emilie,Wengel, Jesper,Koch, Troels
, p. 1131 - 1133 (2007/10/03)
2′-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2′-oxy-LNA up until a late stage intermediate (1).