625111-32-2

Upstream product

• 552856-36-7 1-(2,5-di-O-acetyl-4-C-acetyloxymethyl-3-O-benzyl-β-D-erythro-pentofuranosyl)thymine 
• 552856-35-6 Acetic acid (3S,4R)-4,5-diacetoxy-2-acetoxymethyl-3-benzyloxy-tetrahydro-furan-2-ylmethyl ester 
• 63593-03-3 1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose 
• 65-71-4 thymin 
• 552856-61-8 6-(2-azido-3-O-benzyl-2-deoxy-5-O-benzoyl-4-C-(benzoyloxymethyl)-β-D-erythro-pentofuranosyl)-tetrazolo[1,5-c]pyrimidin-8-methyl-5(6H)-one 
• 552856-56-1 1-(2-O-acetyl-5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-erythro-pentofuranosyl)thymine 
• 552856-57-2 1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-erythro-pentofuranosyl)thymine 
• 552856-59-4 1-(3-O-benzyl-5-O-benzoyl-4-C-benzoyloxymethyl-β-D-threo-pentofuranosyl)thymine 
• 552856-58-3 2,2-anhydro-1-(5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-β-D-threo-pentofuranosyl)thymine 
• 552856-54-9 1,2-di-O-acetyl-5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-D-erythro-pentofuranose 
• 552856-52-7 5-O-benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 552856-40-3 1-(3-O-benzyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)-thymine 
• 552856-41-4 1-[2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-(methanesulfonyloxymethyl)-β-D-erythro-pentofuranosyl]thymine 
• 552856-39-0 1-(3-O-benzyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine 

Downstream Products

• 552856-48-1 (1R,3R,4R,7S)-7-benzyloxy-1-hydroxymethyl-5-methyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Synthesis of locked nucleic acid derivatives

The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising

Improved synthesis of 2′-amino-LNA

2′-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2′-oxy-LNA up until a late stage intermediate (1).

Synthesis of 2′-amino-LNA: A new strategy

In this paper we present revised and significantly improved synthetic routes to 2′-amino-LNA (locked nucleic acid). The optimal route is convergent with the synthesis of LNA monomers ("2′-oxy-LNA") via a common intermediate obtained by a mild deacetylatio

SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES

The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising