625111-41-3

Upstream product

• 4005-49-6 N-benzoyladenine 
• 410076-93-6 3-O-benzyl-1,2-di-O-acetyl-5-O-(methylsulfonyl)-4-C-(methylsulfonyloxymethyl)-α,β-L-threo-pentofuranose 
• 410076-95-8 9-(3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-α-L-threo-pentofuranosyl)-6-N-benzoyladenine 
• 410076-94-7 9-[2-O-acetyl-3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-α-L-threo-pentofuranosyl]-6-N-benzoyladenine 
• 625111-37-7 9-(3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-2-O-trifluormethanesulfonyl-α-L-threo-pentofuranosyl)-6-N-benzoyladenine 

Downstream Products

• 1067885-84-0 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-1-(4,4′-dimethoxytrityloxymethyl)-7-hydroxy-5-(pyren-1-yl)methyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-86-2 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-1-(4,4′-dimethoxytrityloxymethyl)-7-hydroxy-5-(pyren-1-yl)carbonyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-85-1 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-7-[2-cyanoethoxy-(diisopropylamino)phosphinoxy]-1-(4,4′-dimethoxytrityloxymethyl)-5-(pyren-1-yl)methyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-87-3 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-7-[2-cyanoethoxy-(diisopropylamino)phosphinoxy]-1-(4,4′-dimethoxytrityloxymethyl)-5-(pyren-1-yl)carbonyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-77-1 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-7-benzyloxy-1-methanesulfonyloxymethyl-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-78-2 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-7-hydroxy-1-methanesulfonyloxymethyl-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-80-6 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-1-benzoyloxymethyl-7-hydroxy-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-81-7 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-7-hydroxy-1-hydroxymethyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1067885-82-8 (1S,3R,4S,7R)-3-(6-N-benzoyladenin-9-yl)-1-(4,4′-dimethoxytrityloxymethyl)-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

N2′-functionalized 2′-amino-α-L-LNA adenine derivatives - Efficient targeting of single stranded DNA

The synthesis of two pyrene-functionalized 2α-amino-α-L-LNA adenine building blocks is outlined and initial results from thermal denaturation studies are presented. Copyright Taylor & Francis Group, LLC.

Synthesis and characterization of oligodeoxyribonucleotides modified with 2′-amino-α-l-LNA adenine monomers: High-affinity targeting of single-stranded DNA

The development of conformationally restricted nucleotide building blocks continues to attract considerable interest because of their successful use within antisense, antigene, and other gene-targeting strategies. Locked nucleic acid (LNA) and its diaster

Synthesis of locked nucleic acid derivatives

The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising