62517-39-9

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 74401-43-7 2,2-Dimethyl-3-(4-nitro-phenoxy)-1-phenyl-propan-1-one 
• 56010-63-0 2,2-dimethyl-3-hydroxy-1-phenylpropan-1-one 

Downstream Products

• 62517-03-7 2-Chloro-3-[4-(2,2-dimethyl-3-oxo-3-phenyl-propoxy)-phenyl]-propionic acid ethyl ester 

Relevant academic research and scientific papers

Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quarternary carbon atom

A series of 2-chloro-3-(4-alkoxyphenyl)propionic acids containing a quarternary carbon atom in the alkoxy moiety was prepared and the hypolipidemic and hypoglycemic activities were evaluated. Of the 18 compounds synthesized, ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate was the best with respect to biological activity and toxicity. Its functional derivatives and optically resolved enantiomers were also prepared. Structure-activity relationships are discussed briefly.