625437-75-4Relevant academic research and scientific papers
Asymmetric synthesis of antimalarial alkaloids (+)-febrifugine and (+)-isofebrifugine
Huang, Pei-Qiang,Wei, Bang-Guo,Ruan, Yuan-Ping
, p. 1663 - 1667 (2007/10/03)
Diastereoselective α,-amidoalkylation of N,O-acetal, derivated from controlled regio and diastereoselective reduction of (S)-N-(4-methoxybenzyl)-3-silyloxyglutarimide provided two diastereomeric 6-allyl-5-silyloxy-2-piperidinones in 76:24 selectivity. The transformation of the major diastereomer into a known advanced intermediate allowed the synthesis of (+)-febrifugine and (+)-isofebrifugine.
