625437-73-2

Upstream product

• 54848-33-8 (S)-tetrahydro-5-oxo-2-furancarbonyl chloride 
• 100-46-9 benzylamine 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 

Downstream Products

• 87179-79-1 (S)-1-benzyl-5-(benzyloxy)piperidin-2-one 
• 87179-80-4 (S)-1-benzyl-5-hydroxypiperidin-2-one 
• 625437-69-6 (5S,6S)-6-Allyl-1-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-piperidin-2-one 
• 625437-77-6 acetic acid 1-benzyl-3-(tert-butyl-dimethyl-silanyloxy)-6-oxo-piperidin-2-yl ester 
• 625437-75-4 1-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-piperidin-2-one 
• 625437-71-0 1-benzyl-3-(tert-butyl-dimethyl-silanyloxy)-piperidine-2,6-dione 
• 625437-76-5 1-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-piperidin-2-one 
• 625437-74-3 (S)-1-benzyl-3-hydroxypiperidine-2,6-dione 

Relevant academic research and scientific papers

INHIBITORS OF BRUTON'S TYROSINE KINASE

Described herein are compounds and their applications with Bruton's tyrosine kinase inhibitory activity. The described compounds comprise at least a compound of Formula (I), or pharmaceutically acceptable salts thereof. Also described herein are methods for synthesizing such compounds, and their applications in the treatment of diseases: autoimmune diseases or conditions associated with aberrant B-cell proliferation such as rheumatoid arthritis, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Preparation of N-Glycosylhydroxylamines and Their Oxidation to Nitrones for the Enantioselective Synthesis of Isoxazolidines

N-benzyl- and N-methyl-N-glycosylhydroxylamines 3a-i were conveniently obtained by reaction of sugars with N-substituted hydroxylamines according to a novel procedure. Subsequent oxidation occurred at the alkyl group, selectively affording the correspondi

Asymmetric synthesis of antimalarial alkaloids (+)-febrifugine and (+)-isofebrifugine

Diastereoselective α,-amidoalkylation of N,O-acetal, derivated from controlled regio and diastereoselective reduction of (S)-N-(4-methoxybenzyl)-3-silyloxyglutarimide provided two diastereomeric 6-allyl-5-silyloxy-2-piperidinones in 76:24 selectivity. The transformation of the major diastereomer into a known advanced intermediate allowed the synthesis of (+)-febrifugine and (+)-isofebrifugine.