625455-50-7

Upstream product

• 814-68-6 acryloyl chloride 
• 625455-49-4 (1R,1’S,2’S)-1-(2-phenylcyclopropyl)but-3-en-1-ol 
• 110659-58-0 (1S,2S)-trans-1-(hydroxymethyl)-2-phenylcyclopropane 
• 34271-30-2 (1S,2S)-2-phenylcyclopropane-1-carbaldehyde 
• 679429-87-9 1-((1S,2S)-2-Phenyl-cyclopropyl)-but-3-en-1-one 
• 625455-48-3 (1S,1’S,2’S)-1-(2-phenylcyclopropyl)but-3-en-1-ol 

Downstream Products

• 625455-51-8 (6R,1'S,2'S)-6-(2'-phenylcyclopropyl)-5,6-dihydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Total synthesis of marine oxylipins constanolactone A and B

A short, high-yielding synthesis of the marine oxylipins constanolactone A and B was reported. Starting from cinnamyl alcohol (3), the cylopropyl lactone moiety 2 was obtained in 28% yield (11 steps). The second coupling partner, vinyl iodide 1, was isolated in 7 steps and 32% yield. Chromium mediated addition yielded the natural products as a 2:1 mixture (74%).