625455-71-2

Upstream product

• 625455-70-1 (2S)-2-amino-N-(2-aminoethyl)-3-methylbutanamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 6306-52-1 L-valine methylester hydrochloride 

Downstream Products

• 625455-74-5 (2S)-2-isopropyl-1,4,7-tris[(4-methylphenyl)sulfonyl]-1,4,7-triazacyclononane 
• 768358-30-1 4-methyl-N-((1S)-2-methyl-1-{[[(4-methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]amino}ethyl)amino]methyl}propyl)benzenesulfonamide 
• 680186-51-0 (2S)-2-isopropyl-1,4,7-triazacyclono nane 
• 625455-75-6 {2-[((2S)-3-methyl-2-{{[(4-methylphenyl)sulfonyl]amino}butanoyl)amino]ethyl}[(4-methylphenyl)sulfonyl]amino}ethyl-4-methylbenzene sulfonate 

Relevant academic research and scientific papers

The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method.

Using L-valine methyl ester hydrochloride as starting material, the synthesis of (2S)-2-isopropyl-1,4,7-trimethyl-1,4,7-triazacyclononane is described. Various standard Richman-Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.