625455-74-5

Upstream product

• 7146-15-8 D-Valine methyl ester hydrochloride 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 625455-71-2 (2S)-3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}-N-(2-{[(4-methylphenyl)sulfonyl]amino}ethyl)butanamide 
• 625455-70-1 (2S)-2-amino-N-(2-aminoethyl)-3-methylbutanamide 
• 6306-52-1 L-valine methylester hydrochloride 
• 768358-30-1 4-methyl-N-((1S)-2-methyl-1-{[[(4-methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]amino}ethyl)amino]methyl}propyl)benzenesulfonamide 

Downstream Products

• 680186-51-0 (2S)-2-isopropyl-1,4,7-triazacyclono nane 

Relevant academic research and scientific papers

Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: Direct formation of enantiopure systems for circularly polarised luminescence applications

Mono-C-substitution of the 1,4,7-triazacyclononane ring induces formation of single enantiomers of Eu(iii) complexes with nonadentate N6O 3 ligands. The absolute configuration of each complex is determined by the stereogenicity of the C-substituent, revealed by comparison of the sign and sequence of CPL transitions for a series of complexes. The Royal Society of Chemistry 2013.

The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method.

Using L-valine methyl ester hydrochloride as starting material, the synthesis of (2S)-2-isopropyl-1,4,7-trimethyl-1,4,7-triazacyclononane is described. Various standard Richman-Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.