62551-75-1Relevant academic research and scientific papers
Feeding the Heck reaction with alcohol: One-pot synthesis of stilbenes from aryl alcohols and bromides
Colbon, Paul,Barnard, Jonathan H.,Purdie, Mark,Mulholland, Keith,Kozhevnikov, Ivan,Xiao, Jianliang
, p. 1395 - 1400 (2012)
Aryl alcohols are employed as feedstock for the Heck reaction. Keggin-type heteropolyacids catalyse the selective dehydration of the alcohols to styrenes, which, in one-pot, undergo palladium-catalysed Heck arylation with aryl bromides, affording broadly functionalised stilbenes. The choice of solvent is critical for the cascade dehydration-Heck reaction, with electron-rich aryl alcohols preferring a basic medium while electron-deficient ones demanding solvents of lower basicity. Copyright
(E)-2-[p-(β-substituted-vinyl)phenyl]alkanoic acids
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, (2008/06/13)
(E)-2-[p-(β-Substituted-vinyl)phenyl]alkanoic acids represented by the formula (I): STR1 wherein R1 and X are as hereinafter defined, having anti-inflammatory, analgesic, antipyretic and platelet aggregation inhibitory activities.
