62558-62-7Relevant academic research and scientific papers
Mechanochemical aza-vinylogous povarov reactions for the synthesis of highly functionalized 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydro-1,5-naphthyridines
Clerigué, José,Menéndez, J. Carlos,Ramos, M. Teresa
, (2021/05/31)
The aza-vinylogous Povarov reaction between aromatic amines, α-ketoaldehydes or α-formylesters and α,β-unsaturated dimethylhydrazones was carried out in a sequential threecomponent fashion under mechanochemical conditions. Following extensive optimization
Synthesis of 1,4-Benzothiazines via KI/DMSO/O2-Mediated Three-Component Oxidative Cyclization/Coupling
Zhao, Jinwu,Luo, Zhigao,Xu, Jingxiu
, p. 1988 - 1992 (2020/04/29)
A three-component transition-metal-free aerobic method for the generation of 1,4-benzothiazines is reported herein. The KI/DMSO/O2 system was found to be effective for the oxidative cyclization/coupling of 2-aminobenzenethiols, anilines, and methylketones. Hence, various structurally important imino 1,4-benzothiazines were assembled with broad functional group tolerance. Mechanistic studies revealed an initial oxidation of ketone α C?H bonds by the KI/DMSO/O2 oxidative system. (Figure presented.).
One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines
Martinez-Ariza, Guillermo,McConnell, Nicholas,Hulme, Christopher
supporting information, p. 1864 - 1867 (2016/05/19)
A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to preform
Metal-free C-N- and N-N-bond formation: Synthesis of 1,2,3-triazoles from ketones, N-tosylhydrazines, and amines in one pot
Chen, Zhengkai,Yan, Qiangqiang,Liu, Zhanxiang,Zhang, Yuhong
supporting information, p. 17635 - 17639 (2015/02/05)
A novel synthetic approach toward 1,4-disubstitut-ed 1,2,3-triazoles by C-N- and N-N-bond formation has been established under transition-metal-free conditions. Complete control of the regioselectivity was successfully achieved. Commercially available ani
Direct synthesis of α-ketothioamides from aryl methyl ketones and amines via I2-promoted sp3 C-H functionalization
Li, Hong-Zheng,Xue, Wei-Jian,Wu, An-Xin
supporting information, p. 4645 - 4651 (2014/06/23)
A domino reaction that involves the formation of CS and C-N bonds in one process via sp3 C-H functionalization strategy has been developed. This reaction affords an efficient and direct method for the synthesis of α-ketothioamides from aryl met
An unusual 1,2-aryl shift in palladium-catalyzed cross-coupling ethoxycarbonylation of arylboronic acids with α-iminoesters
Qian, Cheng,Chen, Jiayan,Fu, Meiqin,Zhu, Shiya,Chen, Wen-Hua,Jiang, Huanfeng,Zeng, Wei
, p. 6013 - 6022 (2013/09/12)
The Pd-catalyzed cross-coupling ethoxycarbonylation of aryl boronic acids with N-aryl-α-iminoesters affords aryl carboxylic esters via carbonyl-imino σ bond cleavage. This unprecedented mode of reaction allows regioselective installation of the ethoxycarbonyl group into target molecules. Mechanism studies have revealed that an unusual 1,2-aryl shift process is involved in the transformation. The Royal Society of Chemistry.
Preparation of trifluoromethyl-substituted aziridines with in situ generated CF3CHN2
Kuenzi, Stefan A.,Morandi, Bill,Carreira, Erick M.
supporting information; experimental part, p. 1900 - 1901 (2012/05/21)
Direct access to trifluoromethyl-substituted aziridines through the use of a protocol in which trifluoromethyl diazomethane is generated in situ and subsequently undergoes addition to activated imines is reported.
Stereoselective synthesis of cis- and trans-4-acyl-β-lactams from vicinal diketones and ketoaldehydes
Wang, Zhixin,Xu, Jiaxi
experimental part, p. 1711 - 1717 (2012/05/19)
4-Acyl-β-lactams are important synthetic intermediates in both pharmaceutical and organic chemistry. Cis- and trans-4-acyl-β-lactams were synthesized stereoselectively from vicinal diketones via the formation of bulky and less bulky diimines as key interm
AN EFFICIENT PRODEDURE FOR THE SYNTHESIS OF P-ANISIDINE PHENYLGLYOXAL FROM ACETOPHENONE
Desmond, R.,Mills, S.,Volante, R. P.,Shinkai, I.
, p. 379 - 386 (2007/10/02)
An efficient procedure for the oxidation of acetophenone to phenylglyoxal and its subsequent in situ conversion to the title compound is described herein.
