62558-64-9Relevant academic research and scientific papers
An eco-friendly approach for the synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles via a multi-component condensation
Mehrabi, Hossein,Alizadeh-Bami, Farzaneh,Meydani, Azam,Besharat, Soheila
, p. 86 - 95 (2021/04/02)
The synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles was demonstrated via a two-step cyclo-condensation reaction of aryl amines, carbonitriles, and ethyl bromopyruvate or aryl amines and arylglyoxals in ethanol heated under
One-pot, regioselective synthesis of functionalized indole derivatives: A three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone
Alizadeh-Bami, Farzaneh,Asadi, Sara,Dastouri, Fatemeh,Mehrabi, Hossein,Ranjbar-Karimi, Reza
, (2020/09/07)
A metal free, one-pot tandem synthetic routes for functionalized indole derivatives has been established. An efficient three-component reaction was designed with incorporation of Knoevenagel condensation followed by inter-, and intramolecular nucleophilic
Reductive Alkylation of α-Keto Imines Catalyzed by PTSA/FeCl3: Synthesis of Indoles and 2,3′-Biindoles
Naidu, P. Seetham,Kolita, Sinki,Sharma, Meenakshi,Bhuyan, Pulak J.
, p. 6381 - 6390 (2015/06/30)
A simple and efficient method for the synthesis of highly functionalized indoles and biindoles was developed. In the reaction protocol, three components were used in one pot and products were obtained in high yield in an easy workup procedure. The reactio
Studies on isocyanides and related compounds: A facile synthesis of 1,6-dihydro-6-oxopyrazine-2-carboxylic acid derivatives via Ugi four-component condensation
Faggi, Cristina,Garcia-Valverde, Maria,Marcaccini, Stefano,Pepino, Roberto,Pozo, Ma. Cruz
, p. 1553 - 1558 (2007/10/03)
The Ugi four-component condensation (U-4CC) between arylglyoxals 7, amines 6, benzoylformic acid (4) and isocyanides 5 afforded the expected products 8 which were cyclized in a 5+1 fashion with ammonium acetate to give 1,N-disubstituted 4-aryl-1,6-dihydro-6-oxo-5-phenylpyrazine-2-carboxamides 9 in good yields. Evidence for the assigned structures 9 was provided by 13C NMR spectra and X-ray analysis of 9a.
