62558-67-2

Basic information

• Product Name: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid
• Synonyms: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid;3-[(4-hydroxyphenyl)carbamoyl]propanoic acid
• CAS NO: 62558-67-2
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• EINECS: -0
• Mol File: 62558-67-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid(62558-67-2)
• EPA Substance Registry System: 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid(62558-67-2)

Safety Data

• Hazardous Substances Data: 62558-67-2(Hazardous Substances Data)

Usage

General Description

Also known as HOPABA, 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid is a chemical compound with a molecular formula C10H11NO4. It is a derivative of the amino acid tyrosine and is commonly used in organic chemistry research. 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid has potential applications in the pharmaceutical industry for the development of new drugs and therapies. It has been studied for its antioxidant properties and its potential role in the treatment of various medical conditions. In addition, this chemical has also been investigated for its potential use in the field of materials science and biotechnology. Overall, 4-(4'-hydroxy-phenylaMino)-4-oxo-butanoic acid shows promise for a variety of potential applications and is the subject of ongoing research and development.

Upstream product

• 932-98-9 1-chloro-4-nitroso-benzene 
• 305-72-6 α-ketoglutaric acid disodium salt 
• 328-50-7 α-ketoglutaric acid 
• 108-30-5 succinic acid anhydride 
• 123-30-8 4-amino-phenol 

Downstream Products

• 1303982-62-8 C₃₀H₃₁N₅O₆ 
• 10187-21-0 4-(pyrrolidine-2,5–dione–1-yl)phenol 

Relevant articles and documents

An approach for differentiating isozymes. Construction of libraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases

Through synthesis and assays of peptidyl substrates, we could select substrates having peptidyl complementary against lipases. The best substrate showed 20-fold improved Km relative to non-peptidyl substrate. Using this information, we generated selective inhibitors. Lipase activities with peptidyl substrates were represented as fingerprints. Differences in fingerprints reflect different structures near active site of lipases, could be used for generating selective inhibitors.

Chemoselective acylation of amines in aqueous media

Amines are efficiently acylated by both cyclic and acyclic anhydrides by dissolving them in an aqueous medium with the help of a surfactant, sodium dodecyl sulfate (SDS). Cyclic and acyclic anhydrides react with equal ease with an amine, and amines with various stereo-electronic factors react at the same rates with an anhydride. Chemoselective acylation of amines in the presence of phenols and thiols and of thiols in the presence of phenols has been achieved. No acidic or basic reagents are used during the reaction. No Chromatographic separation is required for isolation of the acylated products. Reactions in a neutral aqueous medium, easy isolation of products, and innocuous by-products make the present method a green chemical process. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Symmetric, monofunctionalised polymethine dyes labelling reagents

A symmetric cyanine of the formula: wherein:X is selected from the group consisting of O, S and C(CH3)2;W represents non-metal atoms required to form a benzo-condensed or a naphto-condensed ring;R1 is selected from the group consisting of (CH2)nCH3, (CH2)nSO3- and (CH2)nSO3H, wherein n is an integer selected from 0 to 6 when R1 is (CH2)nCH3, and n is an integer selected from 3 to 6 when R1 is (CH2)nSO3- or (CH2)nSO3H;R2 and R3 are independently selected from the group consisting of H, a sulphonic moiety and a sulphonate moiety;Q is selected from the group consisting of:wherein q is 0 or 1 and D is selected from the group consisting of:-C≡C-G; andwherein A is O or S and G is, or contains a N, O or S nucleophile moiety or is, or contains a moiety capable of reacting with N, O or S nucleophiles.