62564-59-4

Upstream product

• 100-63-0 phenylhydrazine 
• 5334-43-0 5-Amino-4-cyano-1-phenylpyrazole 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 68380-54-1 1-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)hydrazine 
• 1286695-65-5 C₁₈H₁₂FN₇ 
• 304872-42-2 C₁₈H₁₄N₆ 
• 304684-80-8 C₁₈H₁₃ClN₆ 
• 500194-68-3 C₁₈H₁₂N₆ 
• 848222-00-4 C₁₈H₁₁ClN₆ 
• 303227-17-0 C₁₃H₁₀N₆ 
• 1286695-62-2 C₁₈H₁₃N₇ 
• 354131-62-7 5-amino-4-imino-1-phenyl-1H-4,5-dihydropyrazolo[3,4-d]pyrimidine 
• 1221129-33-4 1,5-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-imine 
• 5334-30-5 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1454789-01-5 6-cyano-7-imino-N¹-phenyl-1,7-dihydropyrazolo[3',4':4,5]pyrimido[1,6-a]pyrimidine 
• 1454789-02-6 6-cyano-7-imino-5-ethyl-N¹-phenyl-1, 7-dihydropyrazolo[3', 4':4, 5]pyrimido[1, 6-a]pyrimidine 
• 1454789-05-9 ethyl-7-imino-N¹-phenyl-1,7-dihydropyrazolo[3',4':4,5]pyrimido[1,6-a]pyrimidine carboxylate 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: Anti-inflammatory agents with gastroprotective effect in rats

We report the synthesis of new anti-inflammatory 1,7- dihydropyrazolo[3′,4′:4,5]pyrimido[1,6-a]pyrimidine 5 from aminocyanopyrazole. All compounds were characterized by physical, chemical and spectral studies. Preliminary pharmacological evaluation of the resulting products showed that compounds 5a, b, f (50-100 mg/kg, i.p) are active anti-inflammatory agents in carrageenan-induced rat paw oedema assay, and their effects are comparable to that of acetylsalicylic-lysine (300 mg/kg, i.p.), used as a reference drug. The nature of substituent (Y, R3) had a pronounced effect on the anti-inflammatory activity. Studies of structure-activity relationships have led to selection of compound ethyl-3,5-dimethyl-7-imino-N 1-phenyl-1,7-dihydropyrazolo[3′, 4′:4,5]pyrimido[1,6-a]pyrimidine-6-carboxylate, 5f which exhibited the most potent anti-inflammatory activity. In addition, the compounds 5a, b, f showed a significant gastroprotective effect against HCl/EtOH-induced gastric ulcer.

Design, synthesis and anti-acetylcholinesterase evaluation of some new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives

The target new hybrid molecule types pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines phosphonates 4 and 2-(coumarin-3’’-yl)-7-phenylpyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines 5 were prepared via Michaelis–Arbuzov rearrangement (Arbuzov reaction) of pyrazolotriazolopyrimidines chloride 3a–c, with trialkyl phosphate and Knoevenagel reaction of 2-cyanomethyl derivatives 3d–f with salicylic aldehyde, respectively. The precursors 3 were obtained in two steps starting from aminopyrazole 1. Target compounds 4 and 5 were completely characterized by 1H NMR, 13C NMR, 31P NMR, IR and HRMS. The anti-acetylcholinesterase activity of compounds 4 and 5 was evaluated, and results found indicated that they have possessed significant activities (IC50?=?1.73–39.86?μM), and the preliminary SAR of these compounds was investigated.

Synthesis and biological evaluation of some novel fused pyrazolopyrimidines as potential anticancer and antimicrobial agents

Synthesis and evaluation of anticancer and antimicrobial activity of some novel pyrazolopyrimidines and fused pyrazolopyrimidines are reported. Twelve analogs were selected to be evaluated for their in vitro anticancer potential against a panel of three h

Synthesis of new sulfur-linked 1,2,4-triazolothienopyrimidine and 1,2,4-triazolopyrazolopyrimidine derivatives containing fused heterocyclic pyrimidines

(Chemical Equation Presented) A series of novel bis-heterocyclic compounds 12-20 were synthesized by integrating fused heterocyclic pyrimidines, such as thienopyrimidine and pyrazolopyrimidine into the scaffold of thienotriazolopyrimidines, and pyrazolotriazolopyrimidines through a sulfur-linkage.