Tetrahedron Letters p. 4789 - 4792 (1983)
Update date:2022-08-10
Topics:
Acevedo
Krawczyk
Townsend
A catalytic reduction of the nitrile portion of the trimethylsilyl cyanohydrin 7 to a primary amine has produced an in situ annulation to generate the 3,4,5-trihydro-1,3-diazepin-5-ol ring. This ring substructure has demonstrated important biological significance.
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(1974)
