62565-07-5

Basic information

• Product Name: Propanedioic acid, (4-phenylbutyl)-, dimethyl ester
• CAS NO: 62565-07-5
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Mol File: 62565-07-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (4-phenylbutyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (4-phenylbutyl)-, dimethyl ester(62565-07-5)
• EPA Substance Registry System: Propanedioic acid, (4-phenylbutyl)-, dimethyl ester(62565-07-5)

Safety Data

• Hazardous Substances Data: 62565-07-5(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 66684-74-0 dimethyl (E)-cinnamylidenemalonate 
• 4830-93-7 1-Chloro-4-phenylbutane 
• 108-59-8 malonic acid dimethyl ester 
• 768-56-9 4-Phenylbut-1-ene 

Relevant articles and documents

Hydroalkylation of Unactivated Olefins via Visible-Light-Driven Dual Hydrogen Atom Transfer Catalysis

Radical hydroalkylation of olefins enabled by hydrogen atom transfer (HAT) catalysis represents a straightforward means to access C(sp3)-rich molecules from abundant feedstock chemicals without the need for prefunctionalization. While Giese-type hydroalkylation of activated olefins initiated by HAT of hydridic carbon-hydrogen bonds is well-precedented, hydroalkylation of unactivated olefins in a similar fashion remains elusive, primarily owing to a lack of general methods to overcome the inherent polarity-mismatch in this scenario. Here, we report the use of visible-light-driven dual HAT catalysis to achieve this goal, where catalytic amounts of an amine-borane and an in situ generated thiol were utilized as the hydrogen atom abstractor and donor, respectively. The reaction is completely atom-economical and exhibits a broad scope. Experimental and computational studies support the proposed mechanism and suggest that hydrogen-bonding between the amine-borane and substrates is beneficial to improving the reaction efficiency.