62567-42-4

Usage

Uses

Used in Pharmaceutical Industry:
6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and potential medicinal properties make it a valuable compound in the synthesis of bioactive molecules with therapeutic applications.
Used in Antioxidant Applications:
Due to the presence of a hydroxyl group and a phenyl ring, 6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one is used as an antioxidant in various industries. It can help protect against oxidative stress and damage caused by reactive oxygen species, making it a potential candidate for use in health supplements and cosmetics.
Used in Chemical Synthesis:
6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one is used as a building block in the synthesis of various bioactive molecules. Its versatile structure allows for the development of new compounds with potential applications in medicine, biology, and other fields.
Used in Research and Development:
6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one is used as a research compound to study its potential biological and pharmaceutical properties. Researchers can use 6-(2-HYDROXYPHENYL)-PYRIDAZIN-3(2H)-ONE& to investigate its antioxidant capabilities, medicinal properties, and potential applications in drug development.

InChI:InChI=1/C10H8N2O2/c13-9-4-2-1-3-7(9)8-5-6-10(14)12-11-8/h1-6,13H,(H,12,14)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 298-12-4 Glyoxilic acid 
• 7250-94-4 o-acetoxyacetophenone 
• 90125-51-2 2-hydroxy-4-oxo-4-(2-hydroxyphenyl)butyric acid 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 39499-60-0 6-(2-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Downstream Products

• 77585-94-5 3-chloro-6-(2-hydroxyphenyl)pyridazine 

Relevant academic research and scientific papers

Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease

Based on multitarget-directed ligands approach, through two rounds of screening, a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives were designed, synthesized and evaluated as innovative multifunctional agents against Alzheimer's disease. In vitro biological assays indicated that most of the hybrids were endowed with great AChE inhibitory activity, excellent antioxidant activity and moderate Aβ1-42 aggregation inhibition. Taken both efficacy and balance into account, 12a was identified as the optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils; 81.7% for HuAChE-induced Aβ1-40 aggregation). Moreover, it was equipped with the potential to serve as antioxidant (3.03 Trolox equivalents), metals chelator and anti-neuroinflammation agent for synergetic treatment. Finally, in vivo study demonstrated that 12a, with suitable BBB permeability (log BB = ?0.61), could efficaciously ameliorate cognitive dysfunction on scopolamine-treated mice by regulating cholinergic system and oxidative stress simultaneously. Altogether, these results highlight the potential of 12a as an innovative balanced multifunctional candidate for Alzheimer's disease treatment.

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.

Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone

A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.

Intermediates for preparing hydroxyphenylpyridazinones

5-(5'-Halo-2'-methoxyphenyl)-3,4-dihalo-2(5H)-furanones are prepared by a Friedel-Crafts reaction using a p-haloanisole and a mucohalic acid in the presence of aluminum chloride. They are used as chemical intermediates for preparing hydroxyphenylpyridazinones.

1,1,1-Trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanones

A new synthesis for the preparation of 6-(2-hydrophenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine or its nontoxic acid addition salts. The invention claimed here is the trihalocarbinol intermediates.

3-Chloro-6-phenylpyridazine compounds

Substituted derivatives of 3-chloro-6-phenylpyridazine which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have β-adrenergic blocking and vasodilator activity.