7250-94-4Relevant articles and documents
Thermal and bromide ion-catalyzed rearrangement of benzofuran dioxetanes to 1-oxaspiro[2.5]octa-5,7-dien-4-ones
Adam, Waldemar,Ahrweiler, Michael,Reinhard, Dirk
, p. 6713 - 6718 (1994)
The reaction of the tetrasubstituted benzofuran dioxetanes 2 with various nucleophiles, e.g. Br-, Cl-, I-, and HN(i-Pr)2, was investigated and the unprecedented bromide ion-catalyzed rearrangement to the hithert
A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor
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Paragraph 0043; 0044; 0045; 0046, (2019/01/23)
A medicinal composition for combining thioxanthone paclitaxel and STAT3 inhibitor, comprising an active ingredient and a pharmaceutically acceptable adjuvant, characterized in that the active ingredient is composed of paclitaxel and a STAT3 inhibitor represented by formula (I) (shown in the description), and the mass ratio of the paclitaxel to the STAT3 inhibitor represented by formula (I) in theactive ingredient is (0.18 to 0.32): 1. The compound has an effect on MDA having persistently activated STAT3 activity-MB-468 cell, DU-145 cells had good inhibitory effect.
A carbazole class STAT inhibitors maleic acid salt crystal form II combination pharmaceutical composition and its preparation method
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Paragraph 0039-0042, (2019/02/13)
The invention belongs to the field of medicinal chemistry, and in particular relates to with tumor compound of 4 - (9 - ethyl - 9 H - carbazole - 4 - yl) - 6 - (4 - aminophenyl alkene propionyl) - N - (2 - methyl - 4 H - chromene - 4 - keto) - 1, 3, 5 - triazine - 2 - amine maleic acid salt of a new crystalline form, its preparation method, comprising the composition of said form, said form and said form or comprise the composition of use in the preparation of the medicament, the crystalline form II has good physical and chemical stability, solubility and bioavailability, is suitable for formulation development.